Summary
The effects exerted by the partial dopamine (DA) receptor agonists (−)-3-(3-hydroxyphenyl)-N-n-propylpiperidine [(−)-3-PPP] and transdihydrolisuride (TDHL) on prolactin secretion were compared in male and female rats. Both agents were found to increase prolactin release more than tenfold in female rats. In male rats, in contrast, (−)-3-PPP and TDHL were either without effect or decreased prolactin secretion. It is suggested that this sexually differentiated prolactin response to partial DA agonists reflects a lower responsiveness of lactotroph DA receptors in female than in male rats.
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References
Ariens EJ, Simonis AM, van Rossum JM (1964) Drug-receptor interactions: interaction of one or more drugs with one receptor system. In: Ariens EJ (ed) Molecular pharmacology, Academic Press, pp 119–286
Bédard P, Boucher P, Di Paolo T, Labrie F (1984) Interaction between estradiol, prolactin, and striatal dopaminergic mechanisms. In: Hassler RG, Christ JF (eds) Advances in neurology, vol 40. Raven Press, New York, pp 489–495
Ben-Jonathan N, Oliver C, Weiner HJ, Mical RS, Porter JC (1977) Dopamine in hypophysial portal plasma of the rat during the estrus cycle and throughout pregnancy. Endocrinology 100: 452–458
Butcher RL, Collins WE, Fugo NW (1974) Plasma concentrations of LH, FSH, prolactin, progesterone and estradiol-17 throughout the 4-day estrous cycle of the rat. Endocrinology 94: 1704–1708
Carlsson A (1983) Dopamine receptor agonists: intrinsic activity vs. state of receptor. J Neural Transm 57: 309–315
Carlsson M, Eriksson E, Nilsson C, Carlsson A (1986) Sexually differentiated actions of 3-PPP enantiomers on prolactin secretion. Neuropharmacology 25: 951–954
Carlsson M, Carlsson A, Eriksson E (1987) The intrinsic activities of the partial dopamine receptor agonists (−)-3-PPP and TDHL on pituitary dopamine receptors are lower in female than in male rats. Eur J Pharmacol 142: 39–43
Carlsson M, Eriksson E (1988) The intrinsic activity of (−)-3-PPP (preclamol) on pituitary DA receptors in female rats is enhanced following chronic DA depletion. Life Sci 42: 585–588
Clark D, Hjorth S, Carlsson A (1985) Dopamine receptor agonists: mechanisms underlying autoreceptor selectivity. II Theoretical considerations. J Neural Transm 62: 171–207
Demarest KT, McKay DW, Riegle GD, Moore KE (1981) Sexual differences in tuberoinfundibular dopamine nerve activity induced by neonatal androgen exposure. Neuroendocrinology 32: 108–113
Di Paolo T, Falardeau P (1985) Modulation of brain and pituitary dopamine receptors by estrogen and prolactin. Prog Neuropsychopharmacol Biol Psychiatry 9: 473–480
Donoso AO, Bishop W, Fawcett CP, Krulich L, McCann SM (1971) Effects of drugs that modify brain monoamine concentrations on plasma gonadotropin and prolactin levels in the rat. Endocrinology 89: 774–784
Eriksson E, Modigh K, Carlsson A, Wikström H (1983) Dopamine receptors involved in prolactin secretion pharmacologically characterized by means of 3-PPP enantiomers. Eur J Pharmacol 96: 29–36
Gudelsky GA, Porter JC (1981) Sex-related difference in the release of dopamine into hypophysial portal blood. Endocrinology 109: 1394–1398
Heiman ML, Ben-Jonatahn N (1982) Rat anterior pituitary dopaminergic receptors are regulated by estradiol and during lactation. Endocrinology 111: 1057–1060
Nathan RS, Sachar EJ, Ostrow L, Asnis GM, Halbreich U, Halpern F, Renzi NL, Slotnick V (1983) A preliminary study of sex-related differences in prolactin responses to dopamine blockade and insulin hypoglycemia and in penfluridol plasma levels in schizophrenic patients. Psychopharmacology 80: 46–49
Ojeda SR, Castro-Vazquez A, Jameson HE (1977) Prolactin release in response to blockade of dopaminergic receptors and to TRH injection in developing and adult rats: role of estrogen in determining sex differences. Endocrinology 100: 427–439
Tuomisto J, Männistö P (1985) Neurotransmitter regulation of anterior pituitary hormones. Pharmacol Rev 37: 249–332
Walters JR, Roth RH (1976) Dopaminergic neurons: anin vivo system for measuring drug interactions with presynaptic receptors. Naunyn Schmiedebergs Arch Pharmacol 296: 5–14
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Carlsson, M., Eriksson, E. The partial dopamine receptor agonists (−)-3-PPP and transdihydrolisuride enhance prolactin secretion in female but not in male rats. J. Neural Transmission 77, 211–216 (1989). https://doi.org/10.1007/BF01248933
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DOI: https://doi.org/10.1007/BF01248933