Summary
The developmental change of dopamine β-hydroxylase (DBH) activity in cerebrospinal fluid (CSF) of epileptic children was studied. Non-epileptic children showed lower DBH activity in CSF than adult, and its activity increased with age. In contrast, epileptic children showed no increase in DBH activity with age. DBH in CSF may be a good index of noradrenergic function in child brain. The results on developmental change in DBH in CSF suggest that refractory epilepsy with long term medication has decreased activity in central noradrenergic neurons.
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References
Corcoran ME, Mason ST (1980) Role of forebrain catecholamines in amygdaloid kindling. Brain Res 190: 473–484
De Potter WP, Pham-Huu Chanh C, De Smet FH, De SchaepdryverAF (1976) The presence of dopamine-β-hydroxylase in the cerebrospinal fluid of rabbits and its increased concentration after stimulation of peripheral nerves and cold stress. Neuroscience 1: 523–529
Fujita K, Maruta K, Teradaira R, Beppu H, Ikegame M, Kawai K, Nagatsu T (1982) Dopamine β-hydroxylase activity in human cerebrospinal fluid form various age groups. Clin Chem 28: 1403–1404
Goldstein DJ, Cubeddu LX (1976) Dopamine-β-hydroxylase activity in human cerebrospinal fluid. J Neurochem 26: 193–195
Hiramatsu M, Fujimoto N, Mori A (1982) Catecholamine level in cerebrospinal fluid of epileptics. Neurochem Res 7: 1299–1305
Hurst JF, LeWitt PA, Burns RS, Foster NL, Lovenberg W (1985) CSF dopamine-β-hydroxylase activity in Parkinson's disease. Neurology 35: 565–568
Kopin IJ, Gordon EK, Jimerson DC, Polinsky RJ (1982) Relation between plasma and cerebrospinal fluid levels of 3-methoxy-4-hydroxyphenylglycol. Science 219: 73–75
Laxer KD, Sourkes TL, Fang TY, Young SN, Gauthier SG, Missala K (1979) Monoamine metabolites in the CSF of epileptic patients. Neurology 29: 1157–1161
Lerner P, Goodwin FK, van Kammen DP, Post RM, Major LF, Ballenger JC, Lovenberg W (1978) Dopamine-β-hydroxylase in the cerebrospinal fluid of psychiatric patients. Biol Psychiatry 13: 685–694
Mason ST, Corcoran ME (1979a) Catecholamines and convulsion. Brain Res 170: 497–507
Mason ST, Corcoran ME (1979b) Depletion of brain noradrenaline but not dopamine by intracerebral 6-OHDA potentiates ECS convulsions. J Pharm Pharmacol 31: 209–211
Matsui H, Kato T, Yamamoto C, Fujita K, Nagatsu T (1981) Highly sensitive assay for dopamine-β-hydroxylase activity in human cerebrospinal fluid by high performance liquid chromatography-electrochemical detection: properties of the enzyme. J Neurochem 37: 289–296
Nagatsu T (1977) Dopamine-β-hydroxylase in blood and cerebrospinal fluid. Trends Biochem Sci 2: 217–219
Nagatsu T, Wakui Y, Kato T, Fujita K, Kondo T, Yokochi F, Narabayashi H (1982) Dopamine-β-hydroxylase activity in cerebrospinal fluid of parkinsonian patients. Biomed Res 3: 95–98
Okada T, Ohta T, Shinoda T, Kato T, Ikuta K, Nagatsu T (1976) Dopamine-β-hydroxylase activity in serum and cerebrospinal fluid in neuropsychiatric diseases. Neuropsychobiology 2: 139–144
Suzuki H, Yata J, Kojima K, Nagatsu T (1985) Simple and sensitive assay of dopamine β-hydroxylase in human cerebrospinal fluid by high-performance liquid chromatography with electrochemical detection. J Chromatogr 341: 176–181
Waldmeier PC, Baumann PA, Fehr B, De Herdt P, Maitre L (1984) Carbamazepine decreases catecholamine turnover in the rat brain. J Pharmacol Exp Ther 231: 166–172
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Suzuki, H., Shimohira, M., Iwakawa, Y. et al. Developmental change of dopamine β-hydroxylase activity in cerebrospinal fluid of epileptic and non-epileptic children. J. Neural Transmission 80, 225–230 (1990). https://doi.org/10.1007/BF01245124
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DOI: https://doi.org/10.1007/BF01245124