Summary
The endogenous monoamine oxidase (MAO) inhibitor (tribulin) activity of rat brain was investigated during the course of carrageenan induced acute paw inflammation. The increase in rat brain tribulin activity closely paralleled the time course intensity of the inflammation. The study indicates that, like externally induced stress, internal stress caused by the inflammation induced hyper algesia can also induce augmented brain tribulin activity. The findings, thus, support the hypothesis that tribulin may function as an endogenous endocoid marker of stress.
This is a preview of subscription content, log in via an institution to check access.
References
Anisman H, Kokkonidis L, Sklar LS (1985) Neurochemical consequences of stress. In: Burchfield SR (ed) Stress, psychological and physiological interactions. Hemisphere Publ Corp, Washington, pp 67–98
Armando I, Glover V, Sandler M (1986) Distribution of endogenous benzodiazepine receptor ligand-monoamine oxidase inhibitory activity (tribulin) in tissues. Life Sci 38: 2063–2067
Armando I, Lemoine AP, Ferrini M, Segura ET, Barontini M (1989) Repeated (isolation) stress increases tribulin-like activity in the rat. Cell Mol Neurobiol 9: 115–122
Basbaum AI, Fields HL (1984) Endogenous pain control systems: brain stem spinal pathways and endorphin circuitary. Ann Rev Neurosci 7: 309–338
Bhattacharya SK (1982) Stress by restraining elevates brain prostaglandins in the rat. Neurosci Lett 33: 165–168
Bhattacharya SK, Das N (1984) Effect of carrageenin-induced pedal oedema on rat brain prostaglandins. Neurochem Pathol 2: 163–169
Bhattacharya SK, Das N (1985) Central serotonergic modulation of carrageenan-induced pedal inflammation in rats. Pharm Res 2: 315–318
Bhattacharya SK, Das N (1986) Central catecholaminergic modulation of carrageenan-induced pedal oedema in rats. Res Exp Med 186: 365–374
Bhattacharya SK, Dasgupta G (1988) Central modulation of peripheral inflammation. Indian J Exp Biol 26: 77–84
Bhattacharya SK, Sarkar MK (1986) Effect of some centrally administered putative aminoacid neurotransmitters on carrageenan-induced paw oedema in rats. J Pharm Pharmacol 38: 144–146
Bhattacharya SK, Das N, Mohan Rao PJR (1988a) Brain monoamines during carrageenaninduced acute paw inflammation in rats. J Pharm Pharmacol 40: 518–520
Bhattacharya SK, Glover V, Mclntyre I, Oxenkrug G, Sandler M (1988b) Stress causes an increase in endogenous monoamine oxidase inhibitor activity (tribulin) in rat brain. Neurosci Lett 92: 218–221
Bonta IL (1978) Endogenous modulators of the inflammatory response. In: Vane JR, Ferreira SH (eds) Handbook of experimental pharmacology, vol 50/I. Springer, Berlin Heidelberg New York, pp 523–567
Clow A, Glover V, Armando I, Sandler M (1983) New endogenous benzodiazepine receptor ligand in human urine. Identity with endogenous monoamine oxidase inhibitor? Life Sci 33: 735–741
Clow A, Davidson J, Glover V, Halket JM, Milton AS, Sandler M, Watkins PJ (1989) Isatin and tribulin concentrations are increased in rabbit brain but not liver following pentylenetetrazole administration. Neurosci Lett 107: 327–330
Davis LG, Manning RW, Dawson WE (1984) Putative endogenous ligands to the benzodiazepine receptor: what can they tell us? Drug Dev Res 4: 31–37
Glover V, Reveley MA, Sandler M (1980) A monoamine oxidase inhibitor in human urine. Biochem Pharmacol 29: 467–470
Glover V, Bhattacharya SK, Sandler M, File SE (1981) Benzodiazepines reduce stress-augmented increase in rat urine monoamine oxidase inhibitor. Nature (Lond) 292: 347–349
Glover V, Clow A, Elsworth JD, Armando I, Sandler M (1984) Increased output of endogenous monoamine oxidase inhibitor in stress: a link with the benzodiazepine system? In: Usdin E, Kvetnansky R, Axelrod J (eds) Stress: the role of catecholamines and other neurotransmitters. Gordon and Breach, New York, pp 457–465
Guilbaud G, Kayser V, Benoist JM, Gautron M (1986) Modifications in the responsiveness of rat ventro-basal thalamic neurones at different stages of carrageenin produced inflammation. Brain Res 385: 86–98
Sandler M (1982) The emergence of tribulin. Trends Pharmacol Sci 3: 471–472
Sandler M, Clow A, Watkins PJ, Glover V (1988) Tribulin — an endocoid marker for anxiety in man. Stress Med 4: 215–219
Sharman DF, Stephens DB, Cohen G, Holzbauer M (1987) Variations in the monoamine oxidase inhibitory activity (“tribulin”?) in pig's urine. J Neural Transm 69: 229–242
Winter CA, Risely EA, Nuss GW (1962) Carrageenan-induced oedema in the hind paw of rat as an assay for anti-inflammatory drugs. Proc Soc Exp Biol 111: 544–547
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bhattacharya, S.K., Tripathi, M. & Acharya, S.B. Rat brain endogenous MAO inhibitor (tribulin) activity during carrageenan-induced acute paw inflammation. J. Neural Transmission 84, 135–140 (1991). https://doi.org/10.1007/BF01249117
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01249117