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Effect of phencyclidine on endogeneous excitatory amino acid release from the rat anterior cingulate cortex — an in vivo microdialysis study

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Summary

The effect of systemically administered phencyclidine (PCP) on the extracellular concentration of aspartate (Asp) and glutamate (Glu) in the rat anterior cingulate cortex was investigated using in vivo microdialysis. PCP significantly reduced the K+-evoked release of Asp and Glu, while it had no effect on the basal efflux of Asp and Glu. These results suggest that PCP might inhibit excitatory amino acid (EAA) release through an N-methyl-D-aspartate (NMDA) receptor-mediated mechanism.

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Author notes

  1. Y. Yonezawa

    Present address: Laboratory of Neurochemistry, Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, Kanzaki, Saga

Authors and Affiliations

  1. Laboratory of Neurochemistry, Center for Emotional and Behavioral Disorders, Hizen National Mental Hospital, Kanzaki, Saga

    H. Hondo, K. Hashimoto, T. Matsumoto, M. Hirano & H. Uchimura

  2. Department of Neuropsychiatry, Faculty of Medicine, Kyushu University, Fukuoka, Japan

    T. Kuroki

Authors
  1. Y. Yonezawa
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  2. H. Hondo
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  3. K. Hashimoto
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  4. T. Matsumoto
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  5. M. Hirano
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  6. H. Uchimura
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  7. T. Kuroki
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Yonezawa, Y., Hondo, H., Hashimoto, K. et al. Effect of phencyclidine on endogeneous excitatory amino acid release from the rat anterior cingulate cortex — an in vivo microdialysis study. J. Neural Transmission 94, 235–240 (1993). https://doi.org/10.1007/BF01277028

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  • DOI: https://doi.org/10.1007/BF01277028

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