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Electron microscopic study of human immunodeficiency virus type 1 (HIV-1) core structure: two RNA strands in the core of mature and budding particles

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Summary

The basic structure of human immunodeficiency virus type 1 (HIV-1) has been investigated morphologically; however, the internal structure of HIV-1 core is not well understood. We studied the internal structures by transmission electron microscopy. We modified the method for electron staining of ultrathin sections and processed electron microscopic photographs using a computer. We confirmed that a mature HIV-1 particle had two copies of RNA strands in a cone-shaped core. These two RNA strands formed a coiling structure and interwound each other, and were already present in the late budding stage.

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Authors and Affiliations

  1.  Department of Microbiology, Kinki University School of Medicine, Osaka, Japan, Japan

    T. Takasaki, I. Kurane, H. Aihara & N. Ohkawa

  2.  Life Science Research Institute, Kinki University, Osaka, Japan, Japan

    J. Yamaguchi

Authors
  1. T. Takasaki
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  2. I. Kurane
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  3. H. Aihara
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  4. N. Ohkawa
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  5. J. Yamaguchi
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Received August 19, 1996 Accepted October 2, 1996

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Takasaki, T., Kurane, I., Aihara, H. et al. Electron microscopic study of human immunodeficiency virus type 1 (HIV-1) core structure: two RNA strands in the core of mature and budding particles. Arch. Virol. 142, 375–382 (1997). https://doi.org/10.1007/s007050050083

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  • DOI: https://doi.org/10.1007/s007050050083

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