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Foot-and-mouth disease in swine

II. Some physical-chemical characteristics of antibodies produced by chemically-treated and non-treated foot-and-mouth disease virus

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Summary

The pattern of foot-and-mouth disease antibody formation in swine was similar to that produced in cattle and guinea pigs. In the early stages the antibody appeared to be a macroglobulin of the 19 S-class and the later-appearing antibody a γ-globulin of the 7 S-class. Evidence suggestive of another class of 7S antibody with an electrophoretic mobility faster than the γ2-globulin is presented. The differences in antibodies produced by the various inoculums appeared to be quantitative only. There appeared to be a correlation of the class and level of antibody produced and the degree of resistance to infection with a homologous virus.

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Author notes

  1. P. D. McKercher

    Present address: Plum Island Animal Disease Laboratory, Animal Disease and Parasite Research Division, Agricultural Research Service, U.S. Department of Agriculture, Greenport, Long Island, N. Y., USA

  2. A. R. Giordano

    Present address: Veterans Administration Hospital, 800 Poly Place, Brooklyn, N. Y.

Authors and Affiliations

  1. Plum Island Animal Disease Laboratory, Animal Disease and Parasite Research Division, Agricultural Research Service, U.S. Department of Agriculture, Greenport, Long Island, N. Y., USA

    A. R. Giordano

Authors
  1. P. D. McKercher
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  2. A. R. Giordano
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Additional information

This study is based on part of a dissertation submitted by the senior author in partial fulfillment of the requirements for the DVSc. degree, Graduate School, University of Toronto, Toronto, Ontario, Canada.

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McKercher, P.D., Giordano, A.R. Foot-and-mouth disease in swine. Archiv f Virusforschung 20, 54–70 (1967). https://doi.org/10.1007/BF01245769

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  • DOI: https://doi.org/10.1007/BF01245769

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