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Mutability towards L plaque character of the ECHO virus 19 S particles

II. variation of mutation rate figures in different S clones obtained from the same ECHO virus 19 strain

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Summary

Mutation rates toward the L plaque character in three S clonal populations obtained from a single ECHO virus 19 strain were investigated.

Determinations were performed on monkey kidney (MK) and human embryo (HE) cells respectively in single growth cycle experiment in order to reduce selection favouring the L virus progeny.

Mutation rate figures obtained differed 7.5 fold on MK and 19.4 fold on HE for two S clonal populations exhibiting a number of identical genetic characters.

The fact that mutation rate differences recorded in genetically similar S populations were greater on higher selective host cell system suggests that the apparent variation in mutability consists in dissimilarity concerning growth requirements of the resulted L mutants.

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References

  1. Buimovici-Klein, Elena, Eva Slobodă, R. Klein, C. Voiculesc+u etMaria Ciugarin: Essais de détermination des marqueurs génétiques chez des souches de virus Coxsackie et ECHO de provenance différente. I. Thermostabilité dans l'absence et en présence de la cystine et capacité de réproduction à 37°C et 40°C de quelques virus ECHO. Arch. roum. Path. exp.25, 161 (1966).

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Author notes

  1. Eva Slobodă

    Present address: Cantacuzino Institute Bucharest, Romania

Authors and Affiliations

  1. Cantacuzino Institute Bucharest, Romania

    Elena Buimovici & R. Klein

  2. Enteroviruses and Diagnostic Sera Laboratory, Romania

    Elena Buimovici, Eva Slobodă & R. Klein

Authors
  1. Elena Buimovici
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  2. Eva Slobodă
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  3. R. Klein
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Buimovici, E., Slobodă, E. & Klein, R. Mutability towards L plaque character of the ECHO virus 19 S particles. Archiv f Virusforschung 25, 241–246 (1968). https://doi.org/10.1007/BF01556552

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  • DOI: https://doi.org/10.1007/BF01556552

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