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Studies on interferon induction by Newcastle disease virus (NDV)

I. Interferon induction by NDV grown in primary chick embryonic cells

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Summary

Seed stock of Newcastle disease virus (NDV) prepared by infecting primary chick embryo (PCE) cells (CE-NDV) induced interferon production in PCE cells. Unlike the case of egg-grown NDV (EG-NDV), UV irradiation of CE-NDV resulted in a linear decrease of interferon inducing potency. The interferon induction by CE-NDV was not a strain-specific characteristic, seemed to be associated with viral growth, and was interfered by an excess dose of EG-NDV in its very early period of infection. Little has been elucidated about the mechanism which governs the alteration between EG- and CE-NDV type of interferon stimulation.

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Author notes

  1. S. Kohno

    Present address: Department of Measles Virus, National Institute of Health, Murayama-Branch, Kitatama-gun, Tokyo, Japan

Authors and Affiliations

  1. Department of Measles Virus, National Institute of Health, Murayama-Branch, Kitatama-gun, Tokyo, Japan

    M. Kohase

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  1. S. Kohno
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  2. M. Kohase
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Kohno, S., Kohase, M. Studies on interferon induction by Newcastle disease virus (NDV). Archiv f Virusforschung 28, 177–187 (1969). https://doi.org/10.1007/BF01249382

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  • DOI: https://doi.org/10.1007/BF01249382

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