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Experimental herpesvirus infection of baboons (Papio cynocephalus) and African green monkeys (Cercopithecus aethiops) and recovery of virus by tissue explants

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Summary

Adult African green monkeys and young baboons were inoculated with a baboon-derived herpesvirus (0430) which is antigenically related to herpesvirus SA8. The African green monkeys were not clinically affected, but virus could be recovered from explants. In baboons, pathogenicity was inversely related to age. In intratracheally-inoculated newborns and, to a lesser extent, in intravenously-inoculated newborns, the virus produced severe disease accompanied by weight loss, anorexia, malaise, dyspnea and fever. In 2-month and 1-year-old baboons, the virus produced no clinical symptoms. In all cases, recovery of virus from explants was superior to recovery from tissue homogenates using routine methods.

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Author notes

  1. M. Brack

    Present address: Institute for Neuroanatomy and Histology of the University of Göttingen, Federal Republic of Germany

  2. S. S. Kalter

    Present address: Southwest Foundation for Research and Education, P.O.Box 28147, 78284, San Antonio, TX, USA

Authors and Affiliations

  1. Microbiology and Infectious Diseases, Southwest Foundation for Research and Education, USA

    J. Eichberg, S. S. Kalter, R. L. Heberling & M. Brack

  2. WHO Regional Reference Center for Simian Viruses, San Antonio, Texas, USA

    J. Eichberg, S. S. Kalter, R. L. Heberling & M. Brack

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  1. J. Eichberg
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  2. S. S. Kalter
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  3. R. L. Heberling
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  4. M. Brack
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Eichberg, J., Kalter, S.S., Heberling, R.L. et al. Experimental herpesvirus infection of baboons (Papio cynocephalus) and African green monkeys (Cercopithecus aethiops) and recovery of virus by tissue explants. Archiv f Virusforschung 43, 304–314 (1973). https://doi.org/10.1007/BF01556146

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  • DOI: https://doi.org/10.1007/BF01556146

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