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Efficacy of a virion envelope herpes simplex virus vaccine against experimental skin infections in hairless mice

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Summary

Hairless mice were immunized with herpes simplex virus type 1 (HSV-1) envelope antigen (EAG), EAG in association with polyriboinosinic · polyribocytidylic acid-poly-L-lysine complexed with carboxymethylcellulose (PICLC), and inactivated purified HSV-1 (VAG). After 2 weeks the mice were challenged by a percutaneous HSV-1 infection in the orofacial (OF) or lumbosacral (LS) skin area. Following immunization a consistent cell-mediated immune response was observed in all immunized mice, although the humoral immune response was very low, or not detectable. After challenge, a marked secondary humoral and cell-mediated immune response developed in all immunized mice, and the animals were protected against the development of skin lesions and the fatal outcome of infection. However, the establishment of latent infections in the sensory ganglia was not prevented by the immunization procedure.

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Authors and Affiliations

  1. Department of Microbiology, New York University School of Medicine, New York, USA

    R. J. Klein

  2. Department of Pediatrics, St. Luke's-Roosevelt Hospital Center, Columbia University, New York, USA

    Elena Buimovici-Klein & R. Moucha

  3. Behringwerke AG, Marburg, Federal Republic of Germany

    H. Moser & J. Hilfenhaus

Authors
  1. R. J. Klein
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  2. Elena Buimovici-Klein
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  3. H. Moser
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  4. R. Moucha
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  5. J. Hilfenhaus
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Klein, R.J., Buimovici-Klein, E., Moser, H. et al. Efficacy of a virion envelope herpes simplex virus vaccine against experimental skin infections in hairless mice. Archives of Virology 68, 73–80 (1981). https://doi.org/10.1007/BF01314437

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  • DOI: https://doi.org/10.1007/BF01314437

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