Summary
Seroepidemiological studies of hemorrhagic fever with renal syndrome (HFRS) virus infection were carried out among urban rats(Rattus norvegicus andRattus rattus) and small field rodents in Hokkaido, Japan. An urban rat colony that was seropositive to SR-11 strain of HFRS virus (laboratory rat origin) was demonstrated in February 1983 at a dumping ground area of Kami-iso Town near Hakodate port. An HFRS-related virus, named KI-262 strain, was isolated from the lung tissue of a seropositive rat using Vero-E6 cell culture. Antigenicity of the isolate was closely related to Hantaan 76–118 and SR-11 strains by the indirect immunofluorescent antibody (IFA) test. No seropositive rat was found among the 861 rats captured in 38 other regions. It is unclear whether or not the infected rats in the positive area were introduced from abroad, though the area is located near Hakodate International Port. Furthermore, higher positive rates of urban rats in the Kami-iso area were observed in the spring and winter than in the summer and fall. Significantly high proportion of positive cases was observed among adult rats (six months or older) than among younger animals. The seasonal and age distribution of postive cases suggested that the virus was not readily transmitted from one infected rat to another. One seropostive case of a small field mouse(Clethrionomys rufocanus bedfordiae) was detected around the Kami-iso area.
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Arikawa, J., Takashima, I., Hashimoto, N., Morita, C., Sugiyama, K., Matsuura, Y., Shiga, S., Kitamura, T.: Epidemiological study of hemorrhagic fever with renal syndrome related virus infection among urban rats in two islands in Tokyo Bay, Japan. Acta Virol.29, 66–72 (1985).
Arikawa, J., Takashima, I., Hashimoto, N.: Cell fusion by hemorrhagic fever with renal syndrome (HFRS) viruses and its application for titration of virus infectivity and neutralizing antibody. Arch. Virol.86, 303–313 (1985).
Brummer-Korvenkontio, M., Vaheri, A., Hovi, T., von Bonsdorff, C.-H., Vuorimies, J., Manni, T., Penttinen, K., Oker-Blom, N., Lahdevirta, J.: Nephropathia epidemica: Detection of antigen in bank voles and serologic diagnosis of human infection. J. Infect. Dis.141, 131–136 (1980).
Butkus, D. E.: Epidemic hemorrhagic fever with renal syndrome. Arch. Intern. Med.143, 2299–2300 (1983).
Dai, Z., Xu, Zhiyi, Wang, J., Yang, P., Xu, Z.: Epidemiologic and clinical studies of epidemic hemorrhagic fever. Chinese Med. J.94, 143–148 (1981).
French, G. R., Foulke, R. S., Brand, O. A., Eddy, G. A., Lee, H. W., Lee, P. W.: Korean hemorrhagic fever: Propagation of the etiologic agent in a cell line of human origin. Science211, 1046–1048 (1981).
Gajdusek, D. C.: Hemorrhagic fever with renal syndrome (Korean hemorrhagic fever, epidemic hemorrhagic fever, nephropathia epidemica): A newly recognized zoonotic plague of the Eurasian landmass with the possibility of related muroid virus nephropathies on other continents. In: Viral Disease in South-East Asia and the Western Pacific, 576–594. Australia: Academic Press 1982.
Gavrilevskaya, I. N., Apekina, N. S., Myasnikov, Yu. A., Bernshtein, A. D., Ryltseva, E. V., Gorbachkova, E. A., Chumakov, M. P.: Features of circulation of hemorrhagic fever with renal syndrome (HFRS) virus among small mammals in the European U.S.S.R. Arch. Virol.75, 313–316 (1983).
Hayashi, T., Kikuchi, K., Urasawa, S., Suzuki, A., Yachi, T., Nakao, T., Nagai, H.: Comprehensive reports of epidemic hemorrhagic fever (Korean hemorrhagic fever) observed in Sapporo Medical College in 1981. The Sapporo Med. J.51, supplement K1-K42 (1982).
Inoue, S., Matsuno, S., Kono, R.: Difference in antibody reactivity between complement fixation and immune adherence hemagglutination test with virus antigen. J. Clin. Microbiol.14, 241–246 (1981).
Kim, K. H., Antal, G. M., Shin, H. K.: Epidemiological studies on hemorrhagic nephrosonephritis (Korean hemorrhagic fever) in the Republic of Korea 1971–1973. Korean J. Virol.4, 29–39 (1974).
Kitamura, T., Morita, C., Komatsu, T., Sugiyama, K., Arikawa, J., Shiga, S., Takeda, H., Akao, Y., Imaizumi, K., Oya, A., Hashimoto, N., Urasawa, S.: Isolation of virus causing hemorrhagic fever with renal syndrome (HFRS) through a cell culture system. Japan. J. Med. Sci. Biol.36, 17–25 (1983).
LeDuc, J. W., Smith, G. A., Bagley, L. R., Hasty, S. E., Johnson, K. M.: Preliminary evidence that Hantaan or a closely related virus is enzootic in domestic rodents. New Engl. J. Med.307, 624 (1982).
LeDuc, J. W., Smith, G. A., Johnson, K. M.: Hantaan-like viruses from domestic rats captured in the United States. Amer. J. Trop. Med. Hyg.33, 992–998 (1984).
Lee, H. W., Lee, P. W., Johnson, K. M.: Isolation of the etiological agent of Korean hemorrhagic fever. J. Infect. Dis.137, 298–308 (1978).
Lee, H. W., Lee, P. W., Baek, L. J., Song, C. K., Seong, I. W.: Interspecific transmission of Hantaan virus, etiologic agent of Korean hemorrhagic fever, in the rodent Apodemus agrarius. Am. J. Trop. Med. Hyg.30, 1106–1112 (1981).
Lee, H. W., Baek, L. J., Johnson, K. M.: Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats. J. Infect. Dis.146, 638–644 (1982).
Lee, P. W., Gibbs, C. J., Jr., Gajdusek, D. C., Svedmyr, A.: Antibody to Korean haemorrhagic fever virus in man in parts of the world where haemorrhagic fever with renal syndrome is not known. Lancetii, 256–257 (1981).
Lee, P. W., Amyx, H. L., Gajdusek, D. C., Yanagihara, R. T., Goldgaber, D., Gibbs, C., Jr.: New hemorrhagic fever with renal syndrome-related virus in indigenous wild rodents in United States. Lancetii, 1405 (1982).
LoGrippo, G. A., Hartman, F. W.: Antigenicity of β-propiolactone-inactivated virus vaccines. J. Immunol.75, 123–128 (1955).
McCormic, J. B., Sasso, D. R., Palmer, E. L., Kiley, M. P.: Morphological identification of the agent of Korean hemorrhagic fever (Hantaan virus) as a member of the bunyaviridae. Lanceti, 765–768 (1982).
Morita, C., Sugiyama, K., Matsuura, Y., Kitamura, K., Komatsu, T., Akao, Y., Jitsukawa, W., Sakakibara, H.: Detection of antibody against hemorrhagic fever with renal syndrome (HFRS) virus in sera of houserats captured in port areas of Japan. Japan. J. Med. Sci. Biol.36, 55–57 (1983).
Song, G., Hang, C-s., Qui, X-z., Ni, D-s., Liao, H-x., Gao, G-z., Du, Y-l, Xu, J-k., Wu, Y-s., Zhao, J-n., Kong, B-x., Wang, Z-s., Zhang, Z-q., Shen, H-k., Zhou, N.: Etiologic studies of epidemic hemorrhagic fever (hemorrhagic fever with renal syndrome). J. Infect. Dis.147, 654–659 (1983).
Sugiyama, K., Morita, C., Matsuura, Y., Shiga, S., Komatsu, T., Morikawa, S., Kitamura, T.: Isolation of as virus related to hemorrhagic fever with renal syndrome from urban rats in a nonendemic area. J. Infect. Dis.149, 473 (1984).
Tsai, T. F., Bauer, S. P., Sasso, D. R., McCormic, J. B., Bradford, H., Caraway, C. T., McFarland, L. M., Medrano, O., Soulie, G.: Preliminary evidence that Hantaan or a closely related virus is enzootic in domestic rodents. New Engl. J. Med.307, 623–624 (1982).
Umenai, T., Lee, H. W., Lee, P. W., Saito, T., Toyoda, T., Hongo, M., Yoshinaga, K., Nobunaga, T., Horiuchi, T., Ishida, N.: Korean hemorrhagic fever in staff in an animal laboratory. Lanceti, 1314–1316 (1979).
Working group on haemorrhagic fever with renal syndrome, organized by the WHO regional office for the Western Pacific.: Haemorrhagic fever with renal syndrome: Memorandum from a WHO meeting. Bull. WHO61, 269–275 (1983).
Yabe, T.: Eye lens weight as an age indicator in the Norway rat. J. Mammalog. Soc. Japan8, 54–55 (1979).
Yamanishi, K., Dantas, J. R., Takahashi, M., Yamanouchi, T., Domae, K., Kawamata, J., Kurata, T.: Isolation of hemorrhagic fever with renal syndrome (HFRS) virus from a tumor specimens in a rat. Biken J.26, 155–160 (1983).
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Arikawa, J., Takashima, I., Hashimoto, N. et al. Epidemiological studies of hemorrhagic fever with renal syndrome (HFRS) related virus infection among urban rats in Hokkaido, Japan. Archives of Virology 88, 231–240 (1986). https://doi.org/10.1007/BF01310877
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DOI: https://doi.org/10.1007/BF01310877