Summary
The protective effect of humoral immunity against lethal infection of chickens with Newcastle disease virus was studied.
Chickens hatched from eggs laid by hens vaccinated with live attenuated Newcastle disease virus vaccine possessed antibody to various components of the virus, and were resistant to a challenge with a virulent strain of Newcastle disease virus which was 100 per cent fatal for the offspring of nonvaccinated hens.
Passive administration of antiserum raised against whole virions provided susceptible chickens protection comparable to that seen in the birds with maternal antibody.
When administered passively, both anti-HN serum with virus neutralizing activity, and anti-F serum with only marginal virus neutralizing activity significantly prolonged the survival of infected birds but failed to achieve the level of protection as afforded by the anti-whole NDV serum.
The protection provided by the simultaneous presence of anti-HN and anti-F serum was significantly greater than that afforded by either alone and comparable to that of anti-whole NDV serum, indicating the complementary effect of anti-HN and anti-F antibodies not only in cell cultures as reported previously (19), but also in a natural host.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Abenes G, Kida H, Yanagawa R (1986) Antigenic mapping and functional analysis of the F protein of Newcastle disease virus using monoclonal antibodies. Arch Virol 90: 97–110
Beaudette FR (1943) A review of the literature on Newcastle disease. Proc Ann Meet US Livestock Sanit Ass 47: 122–177
Beaudette FR (1951) Current literature on Newcastle disease. Proc Ann Meet US Livestock Sanit Ass 55: 108–174
Beaudette FR, Bivins JA (1953) The influence of passive immunity on the response to intramuscular and intranasal administration of Newcastle disease virus. Cornell Vet 43: 513–531
Boere WAM, Benaissa-Trouw BJ, Harmsen T, Erich T, Kaaijeveld CA, Snippe H (1985) Mechanisms of monoclonal antibody-mediated protection against virulent Semliki Forest virus. J Virol 54: 546–551
Brandly CA, Moses HE, Jungherr EL (1946) Transmission of antiviral activity via the egg and the role of congenital passive immunity to Newcastle disease in chickens. Am J Vet Res 7: 333–342
Gigli I, Austen KF (1971) Phylogeny and function of the complement system. Ann Rev Microbiol 25: 309–332
Giraudon P, Wild TF (1985) Correlation between epitopes on hemagglutinin of measles virus and biological activities: passive protection by monoclonal antibodies is related to their hemagglutination inhibiting activity. Virology 144: 46–58
Hanson RP (ed) (1964) Newcastle disease virus: an evolving pathogen. The University of Wisconsin Press, Madison, Milwaukee, pp 1–352
Hanson RP (1972) Newcastle disease. In:Hofstad MS, Calnek BW, Helmboldt CF, Reid WM, Yoder HW Jr (eds) Diseases of poultry. The Iowa State University Press, Ames, pp 619–656
Kohama T, Garten W, Klenk H-D (1981) Changes in conformation and charge paralleling proteolytic activation of Newcastle disease virus glycoproteins. Virology 111: 364–376
Lancaster JE (1966) Newcastle disease, a review 1926–1966. (Can Dept Agr Monograph 3) Queen's Printer, Ottawa, pp 1–188
Liddell FDK (1978) Evaluation of survival in challenge experiments. Microbiol Rev 42: 237–249
Löwe A, Rydbeck R, Utter G, Örvell C, Kristensson K, Norrby E (1986) Monoclonal antibodies against the fusion protein are protective in necrotizing mumps meningoencephalitis. J Virol 58: 220–222
Merz DC, Scheid A, Choppin PW (1980) Importance of antibodies to the fusion glycoprotein of paramyxoviruses in the prevention of spread of infection. J Exp Med 151: 275–288
Merz DC, Scheid A, Choppin PW (1981) Immunological studies of the functions of paramyxovirus glycoproteins. Virology 109: 94–105
Nagai Y, Klenk H-D, Rott R (1976) Proteolytic cleavage of the viral glycoproteins and its significance for the virulence of Newcastle disease virus. Virology 72: 494–508
Schmaljohn AL, Johnson ED, Dalrymple JM, Cole GA (1982) Non-neutralizing monoclonal antibodies can prevent lethal alphavirus encephalitis. Nature 297: 70–72
Umino Y, Kohama T, Kohase M, Sugiura A, Klenk H-D, Rott R (1984) Biological functions of monospecific antibodies to envelope glycoproteins of Newcastle disease virus. Arch Virol 81: 53–65
Umino Y, Sato TA, Katow S, Matsuno T, Sugiura A (1985) Monoclonal antibodies directed to El glycoprotein of rubella virus. Arch Virol 83: 33–42
Waterson AP, Pennington TH, Allan WH (1967) Virulence in Newcastle disease virus: A preliminary study. Br Med Bull 23: 138–143
Wolinsky JS, Waxham MN, Server AC (1985) Protective effects of glycoprotein-specific monoclonal antibodies on the course of experimental mumps virus meningoencephalitis. J Virol 53: 727–734
Author information
Authors and Affiliations
Additional information
With 3 Figures
Rights and permissions
About this article
Cite this article
Umino, Y., Kohama, T., Kohase, M. et al. Protective effect of antibodies to two viral envelope glycoproteins on lethal infection with Newcastle disease virus. Archives of Virology 94, 97–107 (1987). https://doi.org/10.1007/BF01313728
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01313728