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An attempt to treat rabies encephalitis in monkeys with intrathecal live rabies virus RV 675

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Summary

A highly attenuated rabies virus, RV 675, proved innocuous but immunogenic when injected intrathecally into monkeys by the lumbar route. Attempts to use this virus to modify the course of fatal rabies encephalitis in monkeys were inconclusive possibly because of the brief encephalitic illness. Further studies are indicated to investigate RV 675 as a candidate therapeutic agent for rabies encephalitis.

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References

  1. Baer GM, Shaddock JH, Williams LW (1975) Prolonging morbidity in rabid dogs by intrathecal injection of attenuated rabies vaccine. Infect Immun 12: 98–103

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Authors and Affiliations

  1. Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

    M. J. Warrell

  2. Sir William Dunn School of Pathology, Oxford University, UK

    M. J. Warrell

  3. Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand

    G. S. Ward, M. R. Elwell & M. Tingpalapong

Authors
  1. M. J. Warrell
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  2. G. S. Ward
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  3. M. R. Elwell
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  4. M. Tingpalapong
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Warrell, M.J., Ward, G.S., Elwell, M.R. et al. An attempt to treat rabies encephalitis in monkeys with intrathecal live rabies virus RV 675. Archives of Virology 96, 271–273 (1987). https://doi.org/10.1007/BF01320967

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  • DOI: https://doi.org/10.1007/BF01320967

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