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Rab7, a multifaceted GTP-binding protein regulating access to degradative compartments in eukaryotic cells

  • Focus on Cellular Biochemistry
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Summary

Small GTPases of the Rab subfamily localise to the cytoplasmic face of distinct membrane compartments and act as regulators of intracellular membrane traffic and transport vesicle formation. Among them, Rab7 controls the delivery of internalised material into degradative compartments and the acquisition of lysosomal hydrolases. This activity shapes the endocytic pathway of every cell type. In addition, this general role may adjust to serve specific needs in multicellular organisms.

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Abbreviations

CI-MPR:

cation-independent mannose 6-phosphate receptor

GAP:

GTPase-activating protein

GDS:

GDP-dissociation stimulator

GEF:

guanine nucleotide exchange factor

LDL:

lowdensity lipoprotein

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Author notes

  1. O. Laurent

    Present address: Unité Mixte de Recherche de CNRS 133, Centre de Recherche de Vitry-Alforville, Rhône-Poulenc-Rorer, Vitry-sur-Seine, France

Authors and Affiliations

  1. Laboratoire de Biochimie et Biophysique des Systèmes Intégrés, Département de Biologie Moléculaire et Structurale, Commissariat à l'Énergie Atomique Grenoble, 17 avenue de Martyrs, F-38054, Grenoble Cedex 9, France

    F. Bruckert, O. Laurent & M. Satre

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Bruckert, F., Laurent, O. & Satre, M. Rab7, a multifaceted GTP-binding protein regulating access to degradative compartments in eukaryotic cells. Protoplasma 210, 108–116 (2000). https://doi.org/10.1007/BF01276850

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