Summary
The present experiments demonstrate that vanadate (sodium orthovanadate) given i.v. to anesthetized cats induces a marked, transient and reversible constriction of visceral arteries, including the renal artery, whereas the femoral and carotid artery escape constriction. The constriction of the renal artery is accompanied by a pronounced reduction of glomerular filtration rate and urine production. The vasoconstriction appears to be caused by a direct effect of vanadate on the vessel wall, but the mechanism of action is not established.
Zusammenfassung
Vanadat wurde als Na3VO4 anästhesierten Katzen i.v. gegeben.Ein deutlicher, kurzzeitiger und reversibler vasokonstriktorischer Effekt wurde registriert an den viszeralen Arterien (auch A. renalis), nicht aber an Femoralarterien und den Karotiden. Die Vasokonstriktion der Nierenarterien ist begleitet von einer hochgradigen Einschränkung der glomerulären Filtrationsrate und der Urinproduktion. Die gemessene Vasokonstriktion scheint die Folge einer direkten Vandatwirkung auf die Gefäßwand zu sein, deren Mechanismus nicht bekannt ist.
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Larsen, J.A., Thomsen, O.Ø. Vascular effects of vanadate. Basic Res Cardiol 75, 428–432 (1980). https://doi.org/10.1007/BF01908406
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DOI: https://doi.org/10.1007/BF01908406