Summary
In isolated guinea pig hearts epicardial perfusion was estimated by analysis of the transit profile of different fluorescence indicators. Several coronary dilating agents were tested with regard to their influence on local perfusion kinetics revealing distinct patterns of microcirculatory drug action.
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Downey, J. M., H. F. Downey, E. S. Kirk: Effects of myocardial strains on coronary blood flow. Cirulat. Res.34, 286–292 (1974).
Haas, H., G. Härtfelder: α-Isopropyl-α [(N-methyl-N-homoveratryl)-γ-aminopropyl)]-3,4-dimethoxyphenylacetonitril, eine Substranz mit coronargefäßerweitenden Eigenschaften. Arzeim.-Forsch.12, 549–558 (1962).
Kamitani, T., K. Nakano, S. Katsuki, F. Honda: Local specificity in responses of canine coronary vessels to oxygen deficiency and antianginal drugs. Arch. Int. Pharmacodyn. Ther.225, 257–274 (1977).
Klaus, W., K. Güttler: Functional and metabolic effects of perhexiline maleate on the isolated myocardium. In: Perhexiline Maleate. Proceedings of a Symposium, eds. A. Fleckenstein, W. Klaus, A. A. Sunhara, G. A. Neuhaus, A. Perrin, pp. 23–32. Excerpta Medica (Amsterdam 1978).
Ono, H., K. Hashimoto: Ca2+-antagonism in various parameters of cardiac function including coronary dilation with the use of nifedipine, perhexiline, and verapamil. In: Ischemic Myocardium and Antianginal Drugs, eds. M. M. Winbury and Y. Abiko, pp. 77–88. Raven Press (New York 1979).
Raff, W. K., F. Kosche, W. Lochner: Extravascular coronary resistance and its relation to microcirculation. Amer. J. Cardiol.29, 598–603 (1972).
Rösen, R., A. Marsen: Differentiation between intra-and extravascular components of local myocardial perfusion. Naunyn-Schmiedeberg's Arch. Pharmacol.311, Suppl. R33 (1980).
Schaper, W.: The measurement of regional myocardial perfusion. In: The Pathophysiology of Myocardial Perfusion, ed. W. Schaper, pp. 9–11. Elsevier/ North-Holland (Amsterdam 1979).
Schnaar, R. L., V. Sparks: Response of large and small coronary arteries to nitroglycerin, NaNO2, and adenosine. Amer. J. Physiol.223, 223–227 (1972).
Wiggers, C. J.: The interplay of vascular resistance and myocardial compression in regulating coronary flow. Circulat. Res.2, 271–279 (1954).
Winbury, M. M., B. B. Howe, A. Hefner: Effect of nitrate and other coronary dilators on large and small coronary vessels: an hypothesis for the mechanism of action of nitrates. J. Pharmacol. Exptl. Ther.168, 70–95 (1969).
Winbury, M. M., L. P. Gabel: Effect of nitrates on nutritional circulation of heart and hindlimb. Amer. J. Physiol.212, 1062–1066 (1967).
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Supported by the Deutsche Forschungsgemeinschaft (SFB 68 A 18)
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Rösen, R., Marsen, A. & Klaus, W. The action of different coronary active drugs on intraand extravascular components of local myocardial perfusion. Basic Res Cardiol 76, 416–420 (1981). https://doi.org/10.1007/BF01908334
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DOI: https://doi.org/10.1007/BF01908334