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Effect of magnesium administered during postischemic reperfusion on myocardial oxidative metabolism in isolated rat hearts

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Summary

To determine the effect of magnesium on myocardial function and oxidative metabolism after reperfusion, isolated rat hearts perfused retrogradely with erythrocyte-enriched medium (0.4 mM palmitate bound to 0.4 mM albumin, 11 mM glucose) were subjected to 60 minutes of no-flow ischemia followed by 60 minutes of reperfusion. Untreated postischemic hearts exhibited after 15 minutes of reperfusion recovery of myocardial oxygen consumption to 65% of the preischemic value despite persistent depression of left ventricular isovolumic pressure development to 21%. Magnesium (15 mM) administered during the initial 30 minutes of reperfusion reduced myocardial oxygen consumption of reperfuse myocardium by 35%. Oxidation of [1-14C]palmitate was slightly more reduced (−55%) than oxidation of [U-14C]glucose(−42%). Magnesium did not influence ultimate recovery of contractile function and cumulative myocardial release of creatine kinase. Thus, 15 mM magnesium administered during reperfusion elicited a reduction of oxidative metabolism. However, magnesium did not modify myocardial injury.

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Authors and Affiliations

  1. Cardiology Center, University Hospital, 1211, Geneva, Switzerland

    Ch. Tamm, I. Papageorgiou, I. Tardy, B. Mermillod, W. Rutishauser & R. Lerch

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  1. Ch. Tamm
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  2. I. Papageorgiou
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  3. I. Tardy
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  4. B. Mermillod
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  5. W. Rutishauser
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  6. R. Lerch
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Supported by the Swiss National Science Foundation grant 32-26373.89 and the Swiss Foundation of Cardiology

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Tamm, C., Papageorgiou, I., Tardy, I. et al. Effect of magnesium administered during postischemic reperfusion on myocardial oxidative metabolism in isolated rat hearts. Basic Res Cardiol 89, 366–379 (1994). https://doi.org/10.1007/BF00795204

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  • DOI: https://doi.org/10.1007/BF00795204

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