Conclusions
Myocardial and skeletal muscular K homeostasis is of importance for the integrity of myocardial function. Myocardial K homeostasis is affected by ischemia. Cardiac failure as well as diuretic therapy may individually and combined lead to dysfunction of K homeostasis. ACE inhibitors and β-adrenoceptor antagonists can beneficially affect K homeostasis explaining the decrease in mortality seen in heart failure patients treated with such drugs. Knowledge concerning the regulation of Na,K-ATPase and its link to K handling may render new insight in the pathophysiology of cardiac disease, and may hence lead to novel therapeutic interventions based on a rational approach.
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Schmidt, T.A., Kjeldsen, K. Myocardial K homeostasis in ischemia-importance of Na,K-ATPase. Basic Res Cardiol 92 (Suppl 2), 57–59 (1997). https://doi.org/10.1007/BF00797212
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DOI: https://doi.org/10.1007/BF00797212