Summary
The interaction of an anticancer drug, 1-(2-tetrahydrofuryl)-5-fluorouracil with sodium poly-α,L-glutamate in aqueous solution was studied with a spectral method and viscosity measurement. From the binding data, the molar change in enthalpy, entropy and the number of binding sites on polymer were calculated. The standard affinity of 1-(2-tetrahydrofuryl)-5-fluorouracil is about −10 kcal/ol with sodium poly-α,L-glutamate. The affinity is also very high.
Zusammenfassung
Die Wechselwirkung zwischen 1-(2-Tetrahydrofuryl)-5-fluorouracil und Na-Poly-α,L-glutamat wurde mit den Methoden der Spektroskopie und der Viskositätsmessung untersucht. Aus den Bindungsdaten wurden die molare Änderung von Entropie und Enthalpie und die Zahl der Brückenstellen des Polymeren berechnet. Der Wert von ΔG° beträgt ca. −10 Kcal/mol. Die Affinität ist also sehr groß.
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References
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Nishida, K., Ando, Y. & Mochinaga, N. Interaction of 1-(2-tetrahydrofuryl)-5-fluorouracil with sodium poly-α,L-glutamate. Colloid & Polymer Sci 259, 350–353 (1981). https://doi.org/10.1007/BF01524715
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DOI: https://doi.org/10.1007/BF01524715