Interaction of 5-trifluoromethyluracil with sodium poly-α,L-glutamate

Abstract

The purpose of our research is to obtain an understanding of the binding mechanism and to the correlations in term of chemical structure and the potentiactive drug activity. The interaction of 5-trifluoromethyluracil (although 5-trifluoromethyluracil do not used as anticancer drug, the structure of the compound has similar structure with 5-fluorouracil) with sodium poly-α,L-glutamate in aqueous solution was studied with a spectral method and viscosity measurement. From the binding data, the molar change in enthalpy, entropy and the number of binding sites on polymer were calculated. It is very interesting that the value ofδH‡ of 5-trifluoromethyluracil is very larger than that of anticancer drug 1-(2-tetrahydrofuryl)-5-fluorouracil. The change of entropy is very large to positive value and so the hydrophobic bonding is probably the predominant factor.