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Antibodies to brain tissue in sera of schizophrenic patients

Preliminary findings

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Summary

The sera of 30 patients suffering from schizophrenia (DSM III) and 30 neurological controls were tested for antibrain antibodies in a blind indirect immunofluorescence assay. We found IgG- and IgM-binding in the sera of 22 patients, but only 4 out of the 30 age- and sex-matched controls. The binding was mainly directed to neurons from the frontal cortex and septal area, areas, which are regarded as important in the development of schizophrenic illness. These preliminary data are presented, to encourage other immunological studies in schizophrenia research.

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Authors and Affiliations

  1. Department of Neurology, University of Ulm, W-7900, Ulm, Germany

    Alexandra E. Henneberg, Silvia Ruffert, Hans-Joachim Henneberg & Hans H. Kornhuber

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  1. Alexandra E. Henneberg
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  2. Silvia Ruffert
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  3. Hans-Joachim Henneberg
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  4. Hans H. Kornhuber
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Henneberg, A.E., Ruffert, S., Henneberg, HJ. et al. Antibodies to brain tissue in sera of schizophrenic patients. Eur Arch Psychiatry Clin Nuerosci 242, 314–317 (1993). https://doi.org/10.1007/BF02190392

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  • DOI: https://doi.org/10.1007/BF02190392

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