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HLA antigen frequencies in patients with huntington's chorea and their relatives

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Summary

Twenty patients with Huntington's chorea and 30 family members were typed for 30 antigens of the HLA-A, B, and C series. There was an increased frequency of HLA-BW 16, significant at the 1%-level. After correcting for multiple inferences, the association of HLA-BW 16 with Huntington's chorea was no longer statistically significant. There was also no reliable indication of coupling between HLA antigens and Huntington's chorea in the family studies.

Zusammenfassung

Bei 20 Patienten mit Chorea Huntington und 30 Angehörigen wurden 30 HLA-Antigene der A-, B- und C-Serie bestimmt. Es fand sich eine Frequenzvermehrung von HLA-BW 16, die auf dem 1%-Niveau signifikant war. Nach einer Korrektur für statistische Fehler ersten Grades bestand keine Signifikanz mehr. Auch bei den Familienuntersuchungen fand sich kein sicherer Hinweis für eine Kopplung der HLA-Antigene mit dem Choreagen.

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Authors and Affiliations

  1. Nervenklinik der Universtität Tübingen und Neurologische Universitätsklinik Mainz, Federal Republic of Germany

    K. Foerster

  2. Blutspendedienst des DRK-Landesverbandes Rheinland-Pfalz, Bad Kreuznach, Federal Republic of Germany

    J. Freudenberg

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  1. K. Foerster
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  2. J. Freudenberg
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Foerster, K., Freudenberg, J. HLA antigen frequencies in patients with huntington's chorea and their relatives. J. Neurol. 223, 119–125 (1980). https://doi.org/10.1007/BF00313174

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  • DOI: https://doi.org/10.1007/BF00313174

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