Summary
Horizontal saccades were examined in 25 patients with hyperthyroidism and/or endocrine ophthalmopathy (EOP) using the infrared reflection method. With one exception none had restriction of horizontal eye movements. Conventional saccadic parameters were usually normal. A standardized test for muscle fatigue, however, gave pathological results in all but one of the patients with EOP, and also in three of seven patients with hyperthyroidism but no clinical EOP. In one of the latter the oculographic abnormality disappeared with treatment, while another developed clinical EOP. Performing a saccadic fatigue test seems to be useful for detecting early EOP and especially for monitoring its course.
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References
Abel LA, Schmidt D, Dell'Osso LF, Daroff RB (1978) Saccadic system plasticity in humans. Ann Neurol 4:313–318
Bahill AT, Stark L (1975) Overlapping saccades and glissades are produced by fatigue in the saccadic eye movement system. Exp Neurol 48:95–106
Bahill AT, Clark MR, Stark L (1975) Dynamic overshoot in saccadic eye movements is caused by neurological control signal reversals. Exp Neurol 48:107–122
Bahill AT, Brockenbrough A, Troost BT (1981) Variability and development of a normative data base for saccadic eye movements. Invest Ophthalmol Vis Sci 21:116–125
Boghen D, Troost BT, Daroff RB, Dell'Osso LF, Birkett JE (1974) Velocity characteristics of normal human saccades. Invest Ophthalmol 13:619–623
Dallow RL, Momose KJ, Weber AL, Wray SH (1976) Comparison of ultrasonography, computerized tomography (EMI SCAN), and radiographic techniques in evaluation of exophthalmos. Trans Am Acad Ophthalmol Otolaryngol 81:305–322
Enzmann D, Marshall WH, Rosenthal AR, Kriss JP (1976) Computed tomography in Graves' ophthalmopathy. Radiology 118:615–620
Feldon SE, Unsöld R (1982) Graves' ophthalmopathy evaluated by infrared eye-movement recordings. Arch Ophthalmol 100:324–328
Feldon SE, Weiner JM (1982) Clinical significance of extraocular muscle volumes in Graves' ophthalmopathy. Arch Ophthalmol 100:1266–1269
Gamblin GT, Harper DG, Galentine P, Buck DR, Chernow B, Eil C (1983) Prevalence of increased intraocular pressure in Graves' disease. Evidence of frequent subclinical ophthalmopathy. N Engl J Med 308:420–424
Gorman CA (1983) Temporal relationship between onset of Graves' ophthalmopathy and diagnosis of thyrotoxicosis. Mayo Clin Proc 58:515–519
Hall R, Ford J, Manson N (1967) Ophthalmic Graves' disease. In: Irvine WJ (ed) Thyrotoxicosis. E and S Livingstone, Edinburgh London, pp 210–220
Hermann JS (1982) Paretic thyroid myopathy. Ophthalmology 89:473–478
Ivy HK (1972) Medical approach to ophthalmopathy of Graves' disease. Mayo Clin Proc 47:980–985
Jensen SF (1971) Endocrine ophthalmoplegia. Is it due to myopathy or to mechanical immobilization? Acta Ophthalmol 49:679–684
Kommerell G, Olivier D, Theopold H (1976) Adaptive programming of phasic and tonic components in saccadic eye movements. Investigations in patients with abducens palsy. Invest Ophthalmol 15:657–660
Manor RS, Kurz O, Lewitus Z (1974) Intraocular pressure in endocrinological patients with exophthalmos. Ophthalmologica 168:241–252
Metz HS (1977) Saccadic velocity studies in patients with endocrine ocular disease. Am J Ophthalmol 84:695–699
Neumann E, Pollak A, Friedman Z, Zeevi YY (1981) Latency of horizontal saccadic eye movements in thyrotoxicosis. Metab Pediatr Syst Ophthalmol 5:111–115
Nikoskelainen E, Enzmann DR, Sogg RL, Rosenthal AR (1977) Computerized tomography of the orbits. Acta Ophthalmol 55:885–900
Schmidt D, Abel LA, Dell'Osso LF, Daroff RB (1979) Saccadic velocity characteristics: intrinsic variability and fatigue. Aviat Space Environ Med 50:393–395
Sergott RC, Glaser JS (1981) Graves' ophthalmopathy. A clinical and immunologic review. Surv Ophthalmol 26:1–21
Solomon DH, Chopra IJ, Chopra U, Smith FJ (1977) Identification of subgroups of euthyroid Graves' ophthalmopathy. N Engl J Med 296:181–186
Spoor TC, Kennerdell JS (1981) Thyrotropin-releasing hormone test and the diagnosis of dysthyroid ophthalmopathy. Ann Ophthalmol 13:443–445
Stark L, Vossius G, Young LR (1962) Predictive control of eye tracking movements. In: Institute of Radio Engineering Transactions on Human Factors in Electronics, HFE-3, pp 52–57
Trokel SL, Jakobiec FA (1981) Correlation of CT scanning and pathologic features of ophthalmic Graves' disease. Ophthalmology 88:553–564
Werner SC (1977) Modification of the classification of the eye changes of Graves' disease. Am J Ophthalmol 83:725–727
Werner SC, Coleman DJ, Franzen LA (1974) Ultrasonographic evidence of a consistent orbital involvement in Graves' disease. N Engl J Med 290:1447–1450
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Mauri, L., Meienberg, O., Roth, E. et al. Evaluation of endocrine ophthalmopathy with saccadic eye movements. J Neurol 231, 182–187 (1984). https://doi.org/10.1007/BF00313935
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DOI: https://doi.org/10.1007/BF00313935