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Quantitative measurement of 4-hydroxy-3-methoxymandelic and homovanillic acids in plasma using capillary gas chromatography-mass spectrometry and stable isotope dilution: Preliminary data

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This report presents a method for the quantitative measurement of 4-hydroxy-3-methoxymandelic acid and homovanillic acid in plasma using gas chromatography, mass fragmentography, and stable isotope dilution. The method is suitable for fast diagnosis of neuroblastoma and for the follow-up of the affected patients: these preliminary results show good discrimination between controls and affected patients.

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Authors and Affiliations

  1. Laboratory of Clinical Chemistry I, G. Gaslini Institute, Genova, Italy

    N. Marchese

  2. Univ. Dept. of Pediatrics I, G. Gaslini Institute, Genova, Italy

    U. Caruso

Authors
  1. N. Marchese
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  2. U. Caruso
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Marchese, N., Caruso, U. Quantitative measurement of 4-hydroxy-3-methoxymandelic and homovanillic acids in plasma using capillary gas chromatography-mass spectrometry and stable isotope dilution: Preliminary data. Chromatographia 36, 179–182 (1993). https://doi.org/10.1007/BF02263858

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  • DOI: https://doi.org/10.1007/BF02263858

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