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An information theory-based evaluation of stationary phases developed for optical resolution of amino acids

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Summary

Naphthylethylurea multiple-bonded chiral stationary phases prepared for the optimal resolution of p-bromophenylcarbamyl derivatives of enantiomeric amino acids are examined from the viewpoint of information theory. The criterion used is the function of mutual information (FUMI) which describes the precision of analysis as a function of peak shape (area and width), overlap and noise level. The length of the polyethyleneamine spacer in the chiral stationary phases is evaluated by the precision (FUMI) calculated from the peak shape and overlap. The best column is defined as the one which gives the highest precision. The temperature effect on the precision is also examined.

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Authors and Affiliations

  1. School of Pharmacy, Hokuriku University, Ho-3 Kanagawa-machi, 920-11, Kanazawa-shi, Ishikawa, Japan

    K. Iwaki & M. Yamazaki

  2. School of Pharmaceutical Science, Kitasato University, 9-1 Shirokane-5, Minato-ku, 108, Tokyo, Japan

    N. Nimura & T. Kinoshita

  3. National Institute of Hygienic Sciences, 1-18-1, Kami-Yoga, Setagaya, 158, Tokyo, Japan

    R. Matsuda & Y. Hayashi

Authors
  1. K. Iwaki
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  2. M. Yamazaki
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  3. N. Nimura
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  4. T. Kinoshita
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  5. R. Matsuda
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  6. Y. Hayashi
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Iwaki, K., Yamazaki, M., Nimura, N. et al. An information theory-based evaluation of stationary phases developed for optical resolution of amino acids. Chromatographia 37, 156–158 (1993). https://doi.org/10.1007/BF02275853

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  • DOI: https://doi.org/10.1007/BF02275853

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