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Enantiomeric resolution of anti-HIV agents on a cellulose derivative chiral stationary phase

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Summary

Anti-HIV enantiomeric 1H, 3H-thiazolo[3, 4-a] benzimidazoles have been stereospecifically analyzed by elution on a column of cellulose tris-(4-methyl-phenylbenzoate)ester adsorbed on macroporous silica (ChiralcelR OJ).

The enantiomeric resolution of the compounds examined is linked to a complex and competitive contribution of different factors.

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Authors and Affiliations

  1. Dipartimento Farmaco-Chimico, Università di Messina, viale Annunziata, 98168, Messina, Italy

    P. Ficarra, R. Ficarra, A. Chimirri, G. Romeo, S. Tommasini, D. Costantino, A. M. Monforte & M. Carulli

  2. Facoltà di Farmacia, Università di Reggio Calabria, Complesso “Barbieri”, 88021, Roccelletta di Borgia (CZ), Italy

    M. L. Calabrò

Authors
  1. P. Ficarra
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  2. R. Ficarra
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  3. A. Chimirri
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  4. G. Romeo
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  5. S. Tommasini
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  6. M. L. Calabrò
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  7. D. Costantino
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  8. A. M. Monforte
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  9. M. Carulli
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Ficarra, P., Ficarra, R., Chimirri, A. et al. Enantiomeric resolution of anti-HIV agents on a cellulose derivative chiral stationary phase. Chromatographia 38, 57–61 (1994). https://doi.org/10.1007/BF02275727

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  • DOI: https://doi.org/10.1007/BF02275727

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