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Determination of traces of salicylic acid in acetylsalicylic acid bulk, tablets and other preparations containing phenacetin and caffeine; Simultaneous determination of salicylic acid, and acetylsalicylic acid with additional components in pharmaceutical preparations

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Summary

A GLC method for the determination of traces of salicylic acid in acetylsalicylic acid bulk, tablets and other preparations containing phenacetin and caffeine after methylation with methyl iodide and potassium carbonate on a column of 3 % OV-17 on Varaport 30, 70–80 mesh, AW/DMCS is reported. A column-chromatographic separation of salicylic acid from acetylsalicylic acid is necessary prior to methylation on account of the slight hydrolysis of the latter. A ferric chloride-urea reagent holds the salicylic acid back on a Celite 545 column. Further, salicylic acid, acetylsalicylic acid, phenacetin, caffeine, barbital, phenobarbital, bromodiethylacetylcarbamide and codein could also be determined simultaneously through GLC using this methylation technique. The chromatogram of such a mixture is presented.

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Authors and Affiliations

  1. Zentrallaboratorium Deutscher Apotheker, Beethovenplatz 1-3, D-6, Frankfurt/Main, West Germany

    S. Laik Ali

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  1. S. Laik Ali
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Laik Ali, S. Determination of traces of salicylic acid in acetylsalicylic acid bulk, tablets and other preparations containing phenacetin and caffeine; Simultaneous determination of salicylic acid, and acetylsalicylic acid with additional components in pharmaceutical preparations. Chromatographia 7, 655–658 (1974). https://doi.org/10.1007/BF02290510

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  • DOI: https://doi.org/10.1007/BF02290510

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