Elsevier

FEBS Letters

Volume 230, Issues 1–2, 28 March 1988, Pages 121-124
FEBS Letters

Modulation of protein kinase C activity by NaF in bone marrow derived macrophages

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Abstract

Stimulation of murine bone marrow derived macrophages with NaF, prelabeled with [1-14C]oleate and [3H]inositol, increased the production of inositol phosphates and the release of 1,2-[14C]diacylglycerol (DAG). Moreover, NaF also induced activation of protein kinase C. These results indicate that bone marrow derived macrophages exhibit a phosphatidyl-4,5-bisphosphate phospholipase C activity, sensitive to NaF, which might be modulated by G-proteins. Activation of protein kinase C could have been mediated by NaF-induced release of DAG.

Keywords

Protein kinase C
NaF
G-protein
Phosphoinositide phospholipase C
(Bone marrow derived macrophage)

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