Elsevier

FEBS Letters

Volume 290, Issues 1–2, 23 September 1991, Pages 27-30
FEBS Letters

Two proteins act as the IUF1 insulin gene enhancer binding factor

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Abstract

IUF1 is a pancreatic β cell-specific factor which binds to the sequence 5′-CPyCTAATG-3′ (CT box) within the human insulin gene enhancer. Here we show that IUF1 is composed of 2 binding activities that can be separated by DEAE ion exchange chromatography. South Western blot analysis indicates that these distinct binding activities have apparent molecular weights of 115 kDa and 46 kDa.

Keywords

Insulin gene
Transcription factor
Gene expression

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