Determination of tryptophan and ten of its metabolites in a single analysis by high-performance liquid chromatography with multiple detection
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Simultaneous determination of tryptophan, kynurenine, kynurenic and xanthurenic acids in honey by liquid chromatography with diode array, fluorescence and tandem mass spectrometry detection
2011, Journal of Chromatography ACitation Excerpt :KYNA has also been determined by UV detection [22,23], or spectrophotometry after derivatization with diazotized sulphanilic acid [24], and less frequently using NMR [25] or tandem mass spectrometry [26,27]. Generally a combination of UV and fluorescent detectors is preferred, although frequently the mobile phases proposed are not compatible with mass spectrometry detectors [28]. Given the lack of studies reporting simultaneous determination by LC of all four compounds in honey, and that the most works are performed on biological matrices [15–28], we sought to develop a solid phase extraction-liquid chromatography with diode array and fluorescence detection (SPE-LC-DAD-FLD) method to simultaneously analysis of TRP, KYNA, KYN and XA in honey samples of distinct botanical origins.
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