Elsevier

Inorganica Chimica Acta

Volume 92, Issue 4, August 1984, Pages 279-284
Inorganica Chimica Acta

The crystal structures and absolute configurations of the anti-tumor complexes Pt(oxalato)(1R,2R-cyclohexanediamine) and Pt(malonato)(1R,2R-cyclohexanediamine)

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Abstract

The absolute configurations of the anti-tumor complexes [Pt(oxalato)(trans-l-dach)] and [Pt(malonato) (trans-l-dach)] (trans-l-dach = 1R,2R-cyclohexanediamine) have been determined by X-ray anomalous scattering techniques. These complexes are particularly interesting because they show higher anti-tumor activity than the corresponding Pt complexes with other 1,2-cyclohexanediamine(dach) ligands, namely those with trans-d-dach (1S,2S-dach) or cis-dach (1R,2S-dach). The oxalato and malonato ligands are found to bind to the Pt atom in a chelating fashion, through one oxygen atom from each of the two carboxylate groups. Crystallographic details: Pt(oxalato)(trans-l-dach): space group P21 (monoclinic); a = 11.230(11) Å, b = 9.914(5) Å, c = 4.716(3) Å, β = 90.86(6)°; R = 4.0% for 1256 reflections. Pt(malonato)(trans-l-dach): space group P21 (monoclinic); a = 11.568(5) Å, b = 10.007(5) Å, c = 5.187(3) Å, β = 99.16(4)°; R = 4.8% for 1675 reflections.

References (25)

  • B. Rosenberg et al.

    Nature

    (1969)
  • M.K. Wolpert DeFilippes et al.
    (1980)
  • T.A. Connors et al.

    Chem. Biol. Interact.

    (1975)
  • M.J. Cleare et al.

    Platinum Metals Rev.

    (1973)
  • G.R. Gale et al.

    Res. Commun. Chem. Pathol. Pharmacol.

    (1974)
  • R.J. Speer et al.

    J. Clin. Hematol. Oncol.

    (1977)
  • Y. Kidani et al.

    J. Med. Chem.

    (1978)
  • M. Noji et al.

    J. Med. Chem.

    (1981)
  • Y. Kidani et al.

    Gann.

    (1980)
  • C.J.L. Lock et al.

    Acta Cryst.

    (1981)
  • K.P. Larsen et al.

    Acta Chemica Scand.

    (1977)
  • Y. Kidani et al.

    J. Clin. Hematol. Oncol.

    (1977)
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