Functional-group modifications of dextran for linkage to a diazonium group. A potential vehicle for tumour targeting of antineoplastic triazenes

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Abstract

Several derivatives of dextran, containing a triazene side-chain, which are analogues of the antitumour agent DTIC (Dacarbazine), were prepared. The extent of triazene incorporation was measured by determination of the nitrogen content, and the presence of triazene groups was corroborated by u.v.- and n.m.r.-spectroscopic measurements. Some dextran-triazenes exhibited cytotoxic activity against M21 tumour cells in vitro.

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Presented, in part, at the Macromolecular Science Symposium during the 64th Chemical Conference and Exhibition of the Chemical Institute of Canada, at Saint Mary's University in Halifax, Nova Scotia (Canada), June 1981.

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