A novel synthesis of -1-[[6-chloro-3-[(2-chloro-3-thienyl)methoxy]-2,3-dihydrobenzo[b]thien-2-yl]methyl]1h-imidazole : A new class of azole antifungal agents
References (11)
- et al.
Advances in Pharmacology and Chemotherapy
(1981) - et al.
- et al.
Hua Hsueh Hsueh Pao
(1956) - et al.
J. Chem. Soc., Perkin Trans. 1
(1972) - et al.
Indian J. Chem.
(1973)
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Synthesis and oxidative transformations of 2-functionalized 2-trifluoromethyltetrahydrothiophenes
2022, Journal of Fluorine ChemistryCitation Excerpt :An alternative method of the preparation of trifluoromethylated 5-membered sulfur-containing heterocycles consists in the ring contraction of CF3-substituted 6-membered heterocycles (compounds A, Scheme 1). Such transformations are known for non-fluorinated tetrahydrothiopyrans bearing potential leaving groups in β-position to sulfur atom, for example, sulfonate [16], p-nitrobenzoate [17], halogens [18,19]. The formation of the rearranged products is explained by the transannular participation of the nucleophilic sulfur atoms and the formation of bicyclic thiiranium cations B, which undergo cleavage by the nucleophiles.
Sulfur-assisted ring contraction of polyfluoroalkylthiopyran derivatives as a route to functionalized fluorine-containing thiophenes
2016, Journal of Fluorine ChemistryCitation Excerpt :The formation of the rearranged products is explained by the transannular participation of the nucleophilic sulfur atoms and the formation of highly reactive bicyclic thiiranium cations, which give 5-membered heterocycles after the cleavage by the nucleophiles. If the initially formed thiolanes or thiolenes contain heterosubstituents, they can undergo subsequent elimination to yield thiophenes [15,17,18]. Recently, we observed the formation of α-trifluoromethylated thiolanes as a result of the sulfur-assisted rearrangement of 6-(trifluoromethyl)-2,3,4-triacetoxytetrahydrothiopyrans [19].
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