Oligodeoxynucleotide analogues containing 3′-deoxy-3′-C-threo-hydroxymethylthymidine: Synthesis, hybridization properties and enzymatic stability
3′-Deoxy-3′-threo-hydroxymethyl nucleoside 4 was stereoselectively synthesized in three steps from 5′-O-(4,4′-dimethoxytrityl)thymidine (1) and subsequently incorporated into oligodeoxynucleotides. Hybridization and enzymatic stability experiments are reported.
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