Chuanbeinone, a novel D/E cis-(22R,25S)-5α-cevanine alkaloid from chinese herbal drug, chuan-bei-mu

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Abstract

A novel D/E cis (22R,25S)-20-deoxy-5α-cevanine alkaloid, chuanbeinone, was isolated from the herbal drug of Fritillaria plant (“chuan-bei-mu” in Chinese), and its absolute configuration was confirmed by X-ray crystallographic analysis.

Chuanbeinone: D/E cis-(22R, 25S)-20-deoxy-5α-cevanine-3β-ol-6-on: was isolated from chinese herbal drug, c̈huan-bei-mü (from some subspecies of Fritillaria delavayi Franch.

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