The synthesis of novel HIV-protease inhibitors

doi:10.1016/S0968-0896(00)82057-X

Bioorganic & Medicinal Chemistry

Volume 2, Issue 10, October 1994, Pages 1075-1083

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Abstract

The syntheses, enzyme inhibition and antiviral activity of potent HIV-protease inhibitors containing novel β-hydroxy ether and thioethers based on the transition state mimetic concept are discussed.

The syntheses and enzyme and antiviral activities of potent HIV-protease inhibitors containing novel β-hydroxy ether and thioethers (e. g. 2) based on the transition state mimetic concept are discussed.

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The synthesis of novel HIV-protease inhibitors

Abstract

Ann. N. Y. Acad. Sci.

J. Virol.

FEBS Lett.

J. Biol. Chem.

Proc. Natl Acad. Sci. U.S.A.

Biochemistry

J. Med. Chem.

Science

J. Biol. Chem.

Science

Proc. Natl. Acad. Sci. U. S. A.

Biochemistry

J. Med. Chem.

Antiviral Res.

Medicinal Research Reviews

Science

J. Med. Chem.

J. Med. Chem.

J. Am. Chem. Soc.