Benzoxepin and benzothiepin derivatives as potent, orally active inhibitors of 5-lipoxygenase

doi:10.1016/S0960-894X(01)80152-9

Bioorganic & Medicinal Chemistry Letters

Volume 4, Issue 4, 24 February 1994, Pages 549-552

https://doi.org/10.1016/S0960-894X(01)80152-9 Get rights and content

Abstract

A series of N-hydroxyurea derivatives based on substituted benzoxepin and benzothiepin templates was prepared and the compounds were evaluated for their ability to inhibit 5-lipoxygenase in vitro and ex vivo.

N-Hydroxyureas based on the benzoxepin and benzothiepin templates were prepared and evaluated in the in vitro guinea pig PMN 5-LO assay and the ex vivo dog model.

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Benzoxepin and benzothiepin derivatives as potent, orally active inhibitors of 5-lipoxygenase

Abstract

Org. Syn. Coll. Vol. VI

Science

Drugs

J. Pharmacol. Exp. Ther.

Thorax

Am. Rev. Respir. Dis.

N. Engl. J. Med.

N. Engl. J. Med.

Lancet

Gastroenterology

Arthritis Rheum.

J. Med. Chem.

Progress in Med. Chem.

J. Am. Chem. Soc.