Two new phospholipase d inhibitors, sch 49211 and sch 49212, produced by the fungus nattrasia mangirferae

https://doi.org/10.1016/S0960-894X(01)80529-1Get rights and content

Abstract

Sch 49211 (2 and Sch 49212 93 have been isolated from the fermentation of the fungus Nattrasia mangiferae. The structures of2 and3 were determined by analysis of NMR spectroscopic data. Both2 and3 exhibit inhibitory activity (IC50 = 11 and 12 μm, respectively) in the phospholipase D (PLD) assay

Two novel phospholipase D inhibitors, Sch49211(2) and SCh49212(3), have been isolated. The structures of2 and3 have been elucidated based on analysis of spectroscopic data.

  1. Download : Download full-size image

Reference (6)

  • ChuM. et al.

    Tetrahedron Lett.

    (1994)
  • ChuM. et al.

    J. Org. Chem.

    (1994)
There are more references available in the full text version of this article.

Cited by (19)

  • Exploring phospholipase D signaling in the Warburg effect and cancer

    2023, Phospholipases in Physiology and Pathology: Volumes 1-7
  • Underpinning the role of phospholipase D as a therapeutic target in cancer

    2023, Phospholipases in Physiology and Pathology: Volumes 1-7
  • One stop mycology

    1995, Mycological Research
View all citing articles on Scopus
View full text