Topical antiinflammatory dehydroabietylamine derivatives. IV
Derivatives of dehydroabietylamine were synthesized and found to be active in the TPA Ear edema assay. An attempt has been made to explain the activity of these compounds based on their biochemical profiles.
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Copper-catalyzed fluoroamide-directed remote benzylic C-H olefination: facile access to internal alkenes
2022, Organic Chemistry FrontiersSyntheses of C-ring modified dehydroabietylamides and their cytotoxic activity
2018, European Journal of Medicinal ChemistryCitation Excerpt :Ammonolysis and subsequent dehydration afforded dehydroabietylamine (Fig. 1), another diterpene with a broad spectrum of pharmacological properties [16]. This tricyclic abietane-type diterpene is modified with an amino moiety at C-18 and derivatives thereof are showing i. a. an antimalarial [17], an antiinflammatory [18], an antibacterial [19], an antiviral [19] and an anticancer potential [20–23]. Several investigations on the cytotoxicity of dehydroabietylamides showed the promising potential of these derivatizations [24–26].
Synthetic derivatives of aromatic abietane diterpenoids and their biological activities
2014, European Journal of Medicinal ChemistryCitation Excerpt :And the imine derivative 62 (Fig. 11) displayed tyrosine kinase inhibitory activity (FGFR1, IC50 = 1.20 μM) [63]. The antioxidative activity of derivative 63 (Fig. 11), which resulted from merging gallic acid and DHAA (5) through an amide bond, has also been reported [64]. Compound 63 was tested for the ability on scavenging superoxide anion radical and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical.
First synthesis of ring-B C<inf>60</inf>-substituted derivatives of N,N-(tetrachlorophthaloyl)dehydroabietylamine
2013, TetrahedronCitation Excerpt :Dehydroabietylamine (Fig. 1), which possesses an aromatic diterpene structure with three rings and three chiral carbon atoms, is the main component of, and can be easily separated from, disproportionated rosin amine. Dehydroabietylamine and its derivatives have been utilised widely because of their biological activities, such as antimicrobial and surface activating activities and the separation of racemic mixtures.20–22 These results prompted us to search for new adducts of dehydroabietylamine with C60 to develop new rosin amine derivatives with potential biological activity.
N,N-Dimethyldehydroabietylammonium chloride ethanol monosolvate
2013, Acta Crystallographica Section E: Structure Reports OnlineN-Benzyl-idenenordehydro-abietylamine
2009, Acta Crystallographica Section E: Structure Reports Online