Synthesis of ingenol analogs wth affinity for protein kinase C

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Abstract

The synthesis and preliminary evaluation of the first biologically active analogs of ingenol are described. Both saturated and unsaturated compounds containing both the C-3 and C-20 oxygen functionalities of ingenol have substantial affinity for protein kinase C.

The synthesis and biological evaluation of 19, the first analog of ingenol, 3, with substantial affinity for protein kinase C, is described.

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1

Recipient of the American Cyanamid Young Faculty Award (1989–1992) and a National Institutes of Health Research Career Development Award (1988–1993).

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