Antiinflammatory β-benzeneethanamines. III

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Abstract

A limited series of β-benzeneethanamines (I) was synthesized and evaluated to determine their antiinflammatory activity, and their ability to inhibit rat polymorphonuclear cell phospholipase-A2, ovine seminal vesicle prostaglandin synthetase, and rat basophilic leukemia cell 5-lipoxygenase.

A limited series of α-benzeneethanamines was synthesized and evaluated to determine their antiinflammatory activity, and their ability to inhibit PLA2, PGS, and 5LO.

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