Biochemical and Biophysical Research Communications
Preadipocytes possess cellular retinoid binding proteins and their differentiation is inhibited by retinoids
References (20)
- et al.
Cell
(1978) - et al.
Arch. Biochem. Biophys.
(1978) - et al.
Biochim. Biophys. Acta
(1973) - et al.
Cell
(1974) - et al.
J. Biol. Chem.
(1978) Clin. Chim. Acta.
(1968)- et al.
J. Biol. Chem.
(1951) - et al.
Biochem. Biophys. Res. Commun.
(1980) - et al.
J. Biol. Chem.
(1975) Biochim. Biophysic. Acta.
(1980)
Cited by (72)
SIRT1 induces the adipogenic differentiation of mouse embryonic stem cells by regulating RA-induced RAR expression via NCOR1 acetylation
2020, Stem Cell ResearchCitation Excerpt :RA has diverse regulatory roles in adipogenesis. In particular, it inhibits the formation of mature adipose tissue from pre-adipocytes (Kuri-Harcuch, 1982; Murray and Russell, 1980; Sato et al., 1980), and thus, may have a suppressive role during late stage adipogenesis. RA treatment also suppresses fat accumulation in diet-induced models of obesity.
RARγ-C-Fos-PPARγ2 signaling rather than ROS generation is critical for all-trans retinoic acid-inhibited adipocyte differentiation
2014, BiochimieCitation Excerpt :Low concentration of RA (1 pM–10 nM range) was shown to promote adipocyte differentiation [44]. In contrast, supraphysiological (0.1–10 μM range) of RA inhibited the differentiation of preadipocytes to adipocytes [18,45]. However, the mechanism of the inhibitory effect of RA on adipocyte differentiation is still largely unknown.
The mechanisms of Fenretinide-mediated anti-cancer activity and prevention of obesity and type-2 diabetes
2014, Biochemical PharmacologyAll-trans retinoic acid modulates bone morphogenic protein 9-induced osteogenesis and adipogenesis of preadipocytes through BMP/Smad and Wnt/β-catenin signaling pathways
2014, International Journal of Biochemistry and Cell BiologyCitation Excerpt :We have previously demonstrated the synergism between RA and BMP9 in inducing osteogenic differentiation of MSCs (Zhang et al., 2010). Moreover, RA was shown to be able to inhibit adipogenic differentiation and cooperate with BMP2 to induce osteogenic differentiation in preadipocytes (Sato et al., 1980; Skillington et al., 2002). These observations suggest the potential of RA to cooperate with BMP9 to promote osteogenesis and reverse BMP9-induced adipogenesis in preadipocytes.
Retinoic acid signaling pathways in development and diseases
2014, Bioorganic and Medicinal ChemistryCitation Excerpt :Major metabolic disorders that are linked with retinoids are obesity, diabetes, and the metabolic syndrome. Multiple studies have documented that RA regulates adipogenesis.63–66 RA acts as a high affinity ligand for the nuclear receptor peroxisome proliferation-activated receptor β/δ (PPARβ/δ).
Alterations in Vitamin A/retinoic acid homeostasis in diet-induced obesity and insulin resistance
2017, Proceedings of the Nutrition Society