A generator for production of 212Pb and 212Bi
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Cited by (32)
Production of <sup>203</sup>Pb from enriched <sup>205</sup>Tl using deuteron beams
2024, Applied Radiation and IsotopesPreparation of <sup>212</sup>Pb-labeled monoclonal antibody using a novel <sup>224</sup>Ra-based generator solution
2017, Nuclear Medicine and BiologyCitation Excerpt :The first generator had problems with radiolytic damage to the resin which caused decreased yields with time and was also associated with serious radiation safety issues. Generator systems based on emanation of 220Rn [14,15] improved radiation safety, but concerns with radiolytic damage were not completely overcome. A generator based on 224Ra [16] has been designed to address challenges arising from use of 228Th-based generators.
Production and in vivo imaging of <sup>203</sup>Pb as a surrogate isotope for in vivo <sup>212</sup>Pb internal absorbed dose studies
2016, Applied Radiation and IsotopesCitation Excerpt :The beta-emitter 212Pb and its immediate daughter radionuclide 212Bi are both promising radionuclides in targeted alpha radiation therapy (TAT) with well-described radiochemistry for antibody linkage (Couturier et al., 2005). Labeling monoclonal antibodies with 212Pb serves as an in vivo generator for the production of 212Bi, so the in vivo effective half-life of 212Bi will be extended (Baidoo et al., 2013; Hassfjell and Hoff, 1994). The other major advantage of applying 212Pb instead of 212Bi in tumor therapy is that 212Pb delivers more than 10 times higher dose compared to 212Bi or 213Bi (Miao et al., 2005; Leichner, 1996).
Radioactive Metals in Imaging and Therapy
2004, Comprehensive Coordination Chemistry IIA <sup>212</sup>Pb generator based on a <sup>228</sup>Th source
2001, Applied Radiation and IsotopesSynthesis, purification and biodistribution of <sup>205</sup>Bi-DOTMP, visualizing bone deposition patterns with autoradiography
2001, Nuclear Medicine and Biology