Decay of 67Cu

doi:10.1016/0375-9474(69)90543-0

Nuclear Physics A

Volume 131, Issue 2, 30 June 1969, Pages 393-397

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Abstract

The γ-rays following the β-decay of ⁶⁷Cu have been investigated with a high-resolution Ge(Li) detector. The ⁶⁷Cu was produced by double neutron capture on ⁶⁵Cu. Gamma rays of energies (and relative intensities) 91.26 (155), 93.25 (360), 184.53 (1000), 208.95 (2.4), 300.22 (15.7) and 393.60 (4.3) keV were observed. The γ-rays have been incorporated in a level scheme of ⁶⁷Zn with levels (and spins and parities) at $0(52^{−}), 93.3 (12^{−}), 184.5 (32^{−}) and 393.5 (32^{−}) keV$ .

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Cited by (17)

Nuclear data sheets for A = 67
2005, Nuclear Data Sheets
Preparation and biodistribution of copper-67-labeled porphyrins and porphyrin-A6H immunoconjugates
1997, Nuclear Medicine and Biology
The synthetic porphyrins, N-benzyl-5,10,15,20-tetrakis(4-carboxyphenyl)porphine (N-bzHTCPP) and N-4-nitrobenzyl-5-(4-carboxyphenyl)-10,15,20-tris(4-sulfophenyl)porphine (N-bzHCS₃P), represent excellent radiocopper chelating agents that may find utility in antibody-mediated diagnosis and/or therapy. N-bzHCS₃P was conjugated to an anti-renal cell carcinoma (RCC) antibody, A6H, and labeled with copper-67. ⁶⁷CuCS₃P-A6H was studied for its biodistribution in human RCC xenograft-bearing nude mice, along with the radiolabeled free porphyrins. The porphyrins resulted in tumor:blood ratios in the range of 3 to 4 after 48 h. The radiolabeled antibody achieved a tumon:blood ratio of over 16 after 45 h, indicating accumulation at the desired site. However, unwanted localization also occurred in the liver and spleen, which will have to be rectified before realizing the full potential of this approach.
Nuclear data sheets update for A = 67
1991, Nuclear Data Sheets
The biological characteristics of a water soluble porphyrin in rat lymph nodes
1990, International Journal of Radiation Applications and Instrumentation.
The biological characteristics of a radiolabeled metalloporphyrin, 5,10,15,20-tetrakis(4-carboxyphenyl)-porphinato [⁶⁷Cu]copper (II) ([⁶⁷Cu]TCPP), in rat lymph nodes, surrounding muscle, fat and blood were determined. Lymphatic tissue localized greater amounts of [⁶⁷Cu]TCPP than did surrounding muscle and fat. Inflamed lymph nodes localized greater amounts of [⁶⁷Cu]TCPP than did noninflamed lymph nodes. Time course studies suggest that the uptake of [⁶⁷Cu]TCPP in noninflamed and in inflamed lymph nodes may involve different biological processes. The affinity of [⁶⁷Cu]TCPP for inflamed lymph nodes may be influenced by the degree of inflammation. If further studies confirm these results, [⁶⁷Cu]TCPP may be useful as a potential radiopharmaceutical for imaging inflamed lymph nodes.
Labeling antibodies with copper radionuclides using N-4-nitrobenzyl-5-(4-carboxyphenyl)-10,15,20-tris(4-sulfophenyl) porphine
1989, International Journal of Radiation Applications and Instrumentation. Part
Antibody conjugates labeled with copper-64 and -67 (⁶⁴Cu and ⁶⁷Cu) were prepared using the porphyrin chelator N-4-nitrobenzyl-5-(4-carboxyphenyl)-10,15,20-tris(4-sulfophenyl) porphine (N-bzHCS₃P). N-bzHCS₃P was chosen because it has only one carboxylate group available for activation and coupling to antibody. The conjugates were characterized with respect to (1) the location of the porphyrin on the antibody, (2) the retention of immunoreactivity, and (3) the serum stability of the amide bond linking porphyrin to antibody. These studies showed that porphyrin attachment on the antibody surface is random. The conjugates exhibited high retention of immunoreactivity and reasonable serum stability for potential application in nuclear medicine.
Preparation and characterization of copper-67 porphyrin-antibody conjugates
1987, Journal of Immunological Methods
Methods were developed to label antibodies with copper-67, a potentially useful medical radioisotope, using the porphyrin chelating agent N-benzyl-5,10,15,20-tetrakis(4-carboxyphenyl) porphine. The porphyrin was activated for coupling using either (1) 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide HCl and N-hydroxysuccinimide or (2) 1,1′-carbonyldiimidazole. The coupling reactions were optimized as a function of activation time, coupling time, coupling pH, and reagent concentrations to achieve maximum coupling to IgG monomer. Sodium dodecylsulfate polyacrylamide gel electrophoresis was used to determine coupling yields. After purification by gel filtration, the antibody-porphyrin conjugates were labeled with copper-67 in aqueous solution. The coupling protocols were used to label antibodies from several species, demonstrating the general utility of these methods. Characterization of the conjugates indicated that the porphyrin label was attached randomly to the IgG molecule. Antigen binding capacities after conjugation were unaltered or slightly lowered as determined by a competitive ELISA.

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^†: Research sponsored by the U.S. Atomic Energy Commission under contract with the Union Carbide Corporation.

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Decay of 67Cu

Abstract

Physica

Nucl. Data

Phys. Lett.

Nucl. Instr.

Phys. Rev.

Nuclear Data Sheets for A = 67

Nucl. Data

Phys. Rev.

Decay of ⁶⁷Cu