Developmental changes of the content of acetyl-CoA carboxylase mRNA in chicken liver☆,☆☆
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Effects of different lipid sources on growth performance, fatty acids composition in tissue and expression of genes related to lipid metabolism in largemouth bass (Micropterus salmoides)
2022, Aquaculture ReportsCitation Excerpt :It has been demonstrated that the lipid or fatty acid metabolism was regulated by hepatic fas in largemouth bass. Malonyl coenzyme A, which is catalyzed by ACC to generate acetyl coenzyme A, is an important substrate for long-chain fatty acid synthesis (Takai et al., 1988; Barber et al., 2005), and ACC is responsible for the introduction of the first double bond of C16:0, C18:0 and therefore associated with the formation of C16:1, C18:1 (Jeffcoat et al., 1977). Although the expression level of acc was regulated by different lipid sources in the diet, there was no difference in the lipid content of the whole body and muscle among different groups, which might be due to the fact that relative expression levels of cpt1, pparα, and hsl were not affected by different lipid sources.
The effect and mechanism of dietary monocalcium phosphate restriction on hepatic lipid deposition and immune status in obscure puffer, Takifugu obscurus
2020, AquacultureCitation Excerpt :It has two isoforms that are encoded by two different genes (Abu-Elheiga et al., 1997). The one is accα, a cytosolic enzyme, whose product (malonyl-CoA) is the committed substrate in the biosynthesis of long-chain fatty acids (Takai et al., 1988). And the other is accβ, a mitochondrial enzyme, and its malonyl-CoA product regulates fatty acid oxidation by inhibiting the shuttle that transports long-chain acyl-CoAs from the cytosol to the mitochondria for oxidation (Abu-Elheiga et al., 1997).
Effect of dietary arachidonic acid levels on growth performance, fatty acid profiles and lipid metabolism of juvenile yellow catfish (Pelteobagrus fulvidraco)
2018, AquacultureCitation Excerpt :Fatty acid synthase (FAS) can catalyze de novo fatty acid synthesis (Cowey and Walton, 1989). Cytosolic enzyme acetyl-CoA carboxylase alpha (ACCα), its production of malonyl-CoA was the pivotal step in the biosynthesis of long-chain fatty acids, which also played a crucial part in biosynthesis of body fatty acids (Takai et al., 1988; Qian et al., 2015). Glucose 6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) were vital regulatory enzymes related with NADPH production, which was essential for fatty acid biosynthesis (Chen et al., 2013; Zheng et al., 2013).
Regulation of growth, antioxidant capacity, fatty acid profiles, hematological characteristics and expression of lipid related genes by different dietary n-3 highly unsaturated fatty acids in juvenile black seabream (Acanthopagrus schlegelii)
2017, AquacultureCitation Excerpt :Furthermore, accα and fas are two genes that play important roles in biosynthesis of body fatty acid (Wakil, 1961). As a key enzyme, the accα's production of malonyl-CoA is a committed step in biosynthesis of long-chain fatty acids (Takai et al., 1988; Zheng et al., 2013), and the function of FAS is to catalyze de novo fatty acid synthesis (Zheng et al., 2013; Cowey and Walton, 1989). In this current experiment, the expression of accα and fas both decreased with increased dietary n-3 HUFA level, and these results were the same as the n-6 PUFAs (C18:2n-6, C18:3n-6, C20:2n-6 and total n-6-PUFA) contents in the liver and muscle.
Factors affecting adipose tissue development in chickens: A review
2017, Poultry Science
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This work was supported by research grants from the Ministry of Health and Welfare, and the Ministry of Education, Science and Culture of Japan.
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The Materials and Methods section and Figs. 1,2, and 4 of this paper appear as a Miniprint Supplement.