Regular ArticleEnhancement of Thrombin Receptor Activation by Thrombin Receptor-Derived Heptapeptide with para-Fluorophenylalanine in Place of Phenylalanine
References (0)
Cited by (38)
Direct evidence of edge-to-face CH/π interaction for PAR-1 thrombin receptor activation
2021, Bioorganic and Medicinal ChemistryCitation Excerpt :As mentioned above, this enhancing effect most strongly affects the benzene CH atoms on the ortho position, but also weakly affects those on the meta and para positions. Such an enhancing effect was observed notably for S/(4-F1)Phe/LLRNP (Fig. 8A), which exhibited the highest activity (250%) among (Fn)Phe-containing homologs.22 Similar notable effects were also observed for S/(2,4,6-F3)Phe/LLRNP (49%), which was approximately four times more potent than S/(2,6-F2)Phe/LLRNP (11%) (Fig. 8B).
The therapeutic potential of proteinase-activated receptors in arthritis
2007, Current Opinion in PharmacologyDifferential receptor binding characteristics of consecutive phenylalanines in μ-opioid specific peptide ligand endomorphin-2
2007, Bioorganic and Medicinal ChemistryProtease-activated receptor-2 (PAR-2): Structure-function study of receptor activation by diverse peptides related to tethered-ligand epitopes
2001, Archives of Biochemistry and BiophysicsThrombin receptor-activating peptides (TRAPs): Investigation of bioactive conformations via structure-activity, spectroscopic, and computational studies
1999, Bioorganic and Medicinal Chemistry
Copyright © 1993 Academic Press. All rights reserved.