Isolation of a novel glycoprotein from the eggs of rainbow trout: Occurrence of disialosyl groups on all carbohydrate chains

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Abstract

The occurrence of disialosyl (α-N-glycolylneuraminyl-(2→8)-N-glycolylneuraminyl) groups has been shown in the carbohydrate chains of a glycoprotein newly isolated from the eggs of rainbow trout. Almost all sialic acid residues form disialosyl sequences at the terminal position of the oligosaccharide units consisting of galactose and N-acetylgalactosamine through which the units are linked to threonine residues of the peptide moiety. The sialic acid content of the glycoprotein was as high as 50%. Such a glycoprotein has not been recognized as a constituent of fish eggs. Its unique sugar and amino acid composition is different from that of any class of the glycoproteins so far reported.

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