Biochemical and Biophysical Research Communications
Differential distribution of the mRNA encoding two isoforms of the catalytic subunit of calcineurin in the rat brain
References (11)
- et al.
Biochem. Biophys. Res. Commun
(1989) - et al.
Biochem. Biophys. Res. Commun
(1989) - et al.
J. Biol. Chem
(1990) - et al.
Neuroscience
(1989) - et al.
Brain Res
(1986)
Cited by (66)
Coexpression of calcineurin A and B subunits in various subcellular and synaptic compartments of cerebellar neurons and glia with particular abundance at parallel fiber-Purkinje cell synapses
2022, Neuroscience ResearchCitation Excerpt :The low or undetectable levels of CNAγ and CNB2 mRNAs were not due to weak probe affinity by low GC contents of the probes used (see Materials and Methods), and were reproduced with use of non-overlapping antisense probes (data not shown). The predominant expression of CNAα, CNAβ, and CNB1 mRNAs in the brain is consistent with previous Northern blot and in situ hybridization (Mukai et al., 1991; Takaishi et al., 1991; Muramatsu et al., 1992; Solà et al., 1999; Eastwood et al., 2005). Therefore, CNB1 is co-transcribed with CNAα and CNAβ in most brain regions, and with all three CNA subunits in the olfactory bulb.
Calcineurin knockout mice show a selective loss of small spines
2018, Neuroscience LettersCitation Excerpt :CNB1 is an isoform of CNB and the only regulatory subunit expressed in the brain. In contrast, several different isoforms of CNA are expressed in the brain [8,9], with the PPP3CC-encoded γ isoform showing single-nucleotide polymorphisms in patients with schizophrenia [10–12]. CNB knockout (CNB-KO) mice exhibit certain behavioral abnormalities typically observed in schizophrenia [13], including impairments in hippocampus-dependent working memory and episodic-like memory, while contextual memory, cued fear conditioning, and spatial reference memory are all preserved [13,14].
Effect of low frequency stimulation on impaired spontaneous alternation behavior of kindled rats in Y-maze test
2016, Epilepsy ResearchCitation Excerpt :Calcineurin is a member of the serine/threonine protein phosphatase family enriched in neural tissue (Pallen and Wang, 1985). It has been found that calcineurin A-α is the predominant isoform in the hippocampus (Takaishi et al., 1991; Kuno et al., 1992; Zhang et al., 1996). Calcineurin mediated dephosphorylation is important in controlling many cellular processes including development of learning and memory (Riedel, 1999; Mansuy, 2003), regulation of long-term potentiation (Wang and Stelzer, 1994) and modulation of neurotransmitter release (Cordeiro et al., 2000).
Identification and characterization of the cDNAs encoding the two subunits of Chinese mitten crab (Eriocheir sinensis) calcineurin: Their implications in stress and immune response
2015, Fish and Shellfish ImmunologyCitation Excerpt :EsCN-B protein shows higher sequence identity than EsCN-A (EsCN-B with 88–94% sequence identity vs. EsCN-A with 80–88% sequence identity) when compared with their corresponding CN proteins from the selected invertebrate and mammalian species. In mammals, CN is most abundant in the central nervous system but it is also detected in a wide variety of non-neuronal tissues [4]. In invertebrate, however, some contrast observations have been reported.
Biochemistry and Pharmacology of Calmodulin-Regulated Phosphatase Calcineurin
2012, Calmodulin and Signal TransductionGenetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy
2007, Journal of Biological Chemistry