In vitro stimulation of steroidogenesis in rat testis by cholera enterotoxin

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Abstract

Cholera enterotoxin increases C-AMP production, and stimulates testosterone secretion in the rat testis in vitro. This gonadotropic action of cholera enterotoxin is potentiated by theophylline. It is suggested that cholera enterotoxin acts on Leydig cells directly to activate their adenyl cyclase, and consequently stimulates steroidogenesis in the rat testis. However, the receptor of cholera enterotoxin seems to be located at a different site from that of human chorionic gonadotropin.

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