Modulation of transient type K channel cloned from rat heart

https://doi.org/10.1016/0006-291X(92)91576-CGet rights and content

Abstract

We have cloned a transient type K channel from rat heart (RH10) and coexpressed a metabotropic glutamate receptor (mGluR5) to study the functional modulation of RH10 coupled to the phosphatidylinositol (PI) hydrolysis. Stimulation of mGluR5 suppressed peak amplitude of RH10 current and affected voltage dependence of activation and inactivation of the channel.

References (21)

  • R.S. Lewis et al.

    Trends Neurosci

    (1988)
  • J.H. Hoger et al.

    Neuron

    (1991)
  • K. Ishii et al.

    Biochem. Biophys. Res. Commun

    (1992)
  • B. Attali et al.

    FEBS Lett

    (1992)
  • D. Schoepp et al.

    Trends Pharmacol. Sci

    (1990)
  • J.C.L. Tseng-Crank et al.

    FEBS Lett

    (1990)
  • B.E. Kemp et al.

    Trends Biochem. Sci

    (1990)
  • T. Abe et al.

    J. Biol. Chem

    (1992)
  • O. Moran et al.

    FEBS Lett

    (1991)
  • B. Hille

    Ionic Channels of Excitable Membranes

    (1991)
There are more references available in the full text version of this article.

Cited by (0)

View full text